This CPB has been revised to (i) restructure medical necessity criteria; and (ii) add criteria for the continued medical necessity of clotting factors. This CPB has been revised to state that Wilate is considered medically necessary for hemophilia A when used for either of the following: members with mild disease who have had an insufficient response to desmopressin or a documented clinical reason for not using desmopressin; and members with moderate or severe disease.