This CPB has been revised with the following: (i) removed requirement for use of Spravato in combination with an oral antidepressant for treatment-resistant depression; (ii) defined "current depressive episode" as beginning with the most recent onset of symptoms; (iii) removed concomitant use of antidepressant and buspirone as an option for augmentation therapy; (iv) specified that the inadequate response with two different antidepressants for at least 8 weeks must have occurred within the past 5 years; (v) specified a timeframe for augmentation therapy trial as 8 weeks within the past 5 years; and (vi) specified evidence based psychotherapy as cognitive behavioral therapy, interpersonal therapy, supportive therapy, or psychoeducational intervention.