Laser Treatment for Psoriasis and Other Selected Skin Conditions

Number: 0577

Table Of Contents

Policy
Applicable CPT / HCPCS / ICD-10 Codes
Background
References

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Policy

Scope of Policy

This Clinical Policy Bulletin addresses laser treatment for psoriasis and other selected skin conditions.

1. Medical Necessity

   Aetna considers the following interventions medically necessary:

   1. Excimer and pulsed dye laser treatment for persons with mild-to-moderate localized plaque psoriasis affecting 10 % or less of their body area who have failed to adequately respond to 3 or more months of topical treatments, including at least 3 of the following:

      1. Anthralin;
      2. Corticosteroids (e.g., betamethasone dipropionate ointment and fluocinonide cream);
      3. Keratolytic agents (e.g., lactic acid, salicylic acid, and urea);
      4. Retinoids (e.g., tazarotene);
      5. Tar preparations; and/or
      6. Vitamin D derivatives (e.g., calcipotriene);

      No more than 13 laser treatments per course and 3 courses per year are generally considered medically necessary. If the person fails to respond to an initial course of laser therapy, as documented by a reduction in Psoriasis Area and Severity Index (PASI) score or other objective response measurement, additional courses are not considered medically necessary.

   2. Laser hair removal for recurrent pilonidal cyst;
   3. The use of laser in acne keloidalis nuchae (AKN) for the following indications:
      
      
      1. Laser excision for treatment of extensive scarring observed in plaque or tumor stage acne keloidalis nuchae (AKN), or
      2. Laser depilation (laser hair removal) for active AKN that is poorly responsive to medical therapy (e.g., oral and topical antibiotics, and intralesional steroids);

   4. Laser treatment for the treatment of penile intraepithelial neoplasia.

2. Experimental and Investigational

   Aetna considers the following interventions experimental and investigational because of insufficient evidence in the peer-reviewed literature and the effectiveness of these approaches has not been established:

   1. Combinational use of pulsed dye laser and ultra-violet B (UVB) for the treatment of persons with localized plaque psoriasis; 
   2. The excimer laser or pulsed dye laser in the treatment of forms of psoriasis other than plaque psoriasis; 
   3. Laser treatment for the following indications (not an all-inclusive list):
      
      
      1. Atopic dermatitis
      2. Cutaneous amyloidosis
      3. Diabetic skin wounds
      4. Dissecting cellulitis
      5. Eczematous lesions
      6. Facial warts (verrucae)
      7. Granuloma annulare
      8. Granuloma faciale
      9. Herpes simplex labialis
      10. Hidradenitis suppurativa
      11. Hidrocystomas
      12. Jessner lymphocytic infiltration of the skin
      13. Keratosis pilaris
      14. Lichen sclerosus
      15. Lupus erythematodes
      16. Melasma
      17. Morphea (scleroderma of the skin)
      18. Mycosis fungoides
      19. Necrobiotic xanthogranuloma
      20. Onychia
      21. Onychomycosis
      22. Prurigo nodularis
      23. Reticular erythematous mucinosis
      24. Sarcoidosis
      25. Spongiotic dermatitis
      26. Vulval intraepithelial neoplasia
      27. Vulvar inflammatory skin conditions.

   4. Ablative laser treatment (non-contact, full-field and fractional ablation) for wound healing.

3. Cosmetic

   Aetna considers laser treatment cosmetic for the following indications (not an all-inclusive list):

   1. Acne scarring
   2. Pearly penile papules
   3. Rhinophyma.

4. Related Policies

   • CPB 0205 - Phototherapy and Photochemotherapy (PUVA) for Skin Conditions
   • CPB 0427 - Carbon Dioxide Laser for Actinic Lesions and Other Selected Indications 
   • CPB 0559 - Pulsed Dye Laser Treatments
   • CPB 0567 - Actinic Keratoses Treatments

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Table:

CPT Codes / HCPCS Codes / ICD-10 Codes

Code	Code Description
CPT codes covered if selection criteria are met:
17110 - 17111	Destruction (eg, laser surgery, electrosurgery, cryosurgery, chemosurgery, surgical curettement), of benign lesions other than skin tags or cutaneous vascular proliferative lesions
17380	Electrolysis epilation, each 30 minutes [laser hair removal]
96920	Laser treatment for inflammatory skin disease (psoriasis); total area less than 250 sq cm
96921	250 sq cm to 500 sq cm
96922	over 500 sq cm
CPT codes not covered for indications listed in the CPB:
0491T	Ablative laser treatment, non-contact, full field and fractional ablation, open wound, per day, total treatment surface area; first 20 sq cm or less
0492T	each additional 20 sq cm, or part thereof (List separately in addition to code for primary procedure)
0552T	Low-level laser therapy, dynamic photonic and dynamic thermokinetic energies, provided by a physician or other qualified health care professional
Other CPT codes related to the CPB:
96900	Actinotherapy (ultraviolet light)
96910	Photochemotherapy; tar and ultraviolet B (Goeckerman treatment) or petrolatum and ultraviolet B
96913	Photochemotherapy (Goeckerman and/or PUVA) for severe photoresponsive dermatoses requiring at least 4 to 8 hrs of care under direct supervision of the physician (includes applications of medication and dressings)
HCPCS codes not covered for indications listed in the CPB:
S8948	Application of a modality (requiring constant provider attendance) to one or more areas; low-level laser; each 15 minutes
Other HCPCS codes related to the CPB:
J3300	Injection, triamcinolone acetonide, preservative free, 1 mg
J3301	Injection, triamcinolone acetonide, not otherwise specified, 10 mg
ICD-10 codes covered if selection criteria are met:
D29.0	Benign neoplasm of penis [penile intraepithelial neoplasia]
L05.01 - L05.92	Pilonidal cyst and sinus
L40.0 - L40.9	Psoriasis
L73.0	Acne keloid
ICD-10 codes not covered for indications listed in the CPB (not all-inclusive):
B00.1	Herpesviral vesicular dermatitis
B07.8	Other viral warts [facial warts]
B35.1	Tinea unguium
C84.00 - C84.09	Mycosis fungoides
D07.1	Carcinoma in situ of vulva
D23.0 - D23.9	Other benign neoplasms of skin [hidrocystomas]
D76.3	Other histiocytosis syndromes [necrobiotic xanthogranuloma]
D86.0 - D86.0	Sarcoidosis
E08.621, E08.622, E08.628, E09.621, E09.622, E09.628, E10.621, E10.622, E10.628, E11.621, E11.622, E11.628, E13.621, E13.622, E13.628	Diabetes with ulcer or other skin complications
E85.4	Organ-limited amyloidosis [cutaneous amyloidosis]
L03.011 - L03.019	Cellulitis of finger
L03.031 - L03.039	Cellulitis of toe
L20.0 - L20.9	Atopic dermatitis
L23.0 - L27.9	Contact dermatitis and other eczema
L28.1	Prurigo nodularis
L71.1	Rhinophyma
L73.2	Hidradenitis suppurativa
L81.0 - L81.9	Other disorders of pigmentation [melasma]
L85.8	Other specified epidermal thickening [Keratosis pilaris]
L90.0	Lichen sclerosus et atrophicus
L90.5	Scar conditions and fibrosis of skin [acne scar]
L91.0	Hypertrophic scar
L92.0	Granuloma annulare
L92.2	Granuloma faciale
L93.0 - L93.2	Lupus erythematosus
L94.0	Localized scleroderma [morphea]
L98.5	Mucinosis of the skin
L98.8	Other specified disorders of the skin and subcutaneous tissue [jessner lymphocytic infiltration of the skin]
N76.2	Acute vulvitis
N76.89	Other specified inflammation of vagina and vulva
N90.0	Mild vulvar dysplasia
N90.1	Moderate vulvar dysplasia
R23.8	Other skin changes [penile papules]

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Background

Plaque Psoriasis

Psoriasis is a chronic skin disease that generally appears as patches of raised red skin covered by a flaky white buildup.  Although the exact cause is unknown, psoriasis is thought to be due to an immunologic dysfunction, which accelerates the growth cycle of skin cells, causing them to accumulate faster than they can be shed. 

Approximately 80 % of persons with psoriasis have "plaque psoriasis".  Plaque psoriasis can appear on any skin surface, although the knees, elbows, scalp, trunk and nails are the most common locations.  There are several other types of psoriasis, and between 10 % and 30 % of people with psoriasis also develop psoriatic arthritis.

Treatments for psoriasis can be divided into 3 basic categories:

1. sunlight and topical agents (corticosteroids, calcipotriene, anthralins, tazarotene, coal tar, salicylic acid, moisturizers);
2. phototherapy (broad-band ultraviolet-B [UVB], PUVA); and
3. systemic medications (methotrexate, oral retinoids, cyclosporine). 

Excimer lasers [XTRAC Excimer Laser Treatment System, (PhotoMedex, Carlsbad, CA) and EX-308 Excimer Laser System (Ra Medical Systems, Carlsbad, CA)] have been cleared by the Food and Drug Administration based on 510(k) applications for treatment of mild-to-moderate localized psoriasis.  Both the XTRAC and the EX-308 are hand-held laser devices that use xenon chloride sources and provide intense, targeted UVB light.  The potential benefits over standard UVB treatments are in terms of more rapid clinical response and more targeted therapy, avoiding the side effects of UV light exposure to unaffected skin.  This procedure is usually repeated at least twice-weekly for 2 to 4 weeks.

There is evidence from controlled clinical trials of the effectiveness of excimer laser treatment of mild-to-moderate psoriasis.  However, the comparative effectiveness of topical and laser treatment of psoriasis is unknown because these treatments have not been directly compared in a prospective clinical study.  In addition, there is no adequate evidence of the effectiveness of laser therapy in combination with topical therapy.  There is also limited evidence of the durability of the response to laser treatment of psoriasis.  There is some evidence that a significant proportion of patients with psoriasis that is refractory to topical therapies may respond to laser treatment.

Asawanonda et al (2000a) reported on a dose-response study involving 13 patients with psoriasis plaques.  Varying numbers of excimer pulses were delivered at fixed doses with a range of fluences from sub-erythemogenic to supra-erythemogenic.  Lesions remained in remission with as few as a single high fluence (up to 16 times the minimal erythemogenic dose (MED)) treatment, whereas recurrences occurred in lesions treated with multiple doses of lower fluences shortly after cessation of treatment.  The duration of remissions seen with the high fluences was 6.5 months.  Based on these findings, the authors stated that "[w]e speculate that the ideal approach for localized, limited plaques may well be single or at most a few 'high-dose' treatments, whereas for widespread psoriasis several 'medium-dose' treatments may make more sense".

Feldman et al (2002) reported on a multi-center study of the excimer laser involving 124 patients with stable mild-to-moderate plaque-type psoriasis; 32 of whom dropped out of the study before completing the course of treatment.  Patients were scheduled twice-weekly for a total of 10 treatments.  Seventy-two percent of patients who completed the treatment course achieved at least 75 % clearing in an average of 6.2 treatments.  Eighty-four percent of patients reached improvement of 75 % or better after 10 or fewer treatments.  Side effects included erythema in half of the 124 patients, blisters in 56 %, hyper-pigmentation in 47 %, and erosion in 31 %.  Other side effects included pain, sunburn sensation, scaling, itching, tenderness, flaking, peeling, vesicles, disease flare, scab, and weeping lesions.  The authors concluded that the excimer laser appears to be safe and effective for psoriasis, and has an advantage over conventional photo-chemotherapy in that it requires fewer visits and targets only the affective areas of skin, sparing the surrounding uninvolved skin.

Trehan and Taylor (2002) reported on a self-controlled study involving 16 with multiple stable psoriasis plaques who were treated with the excimer laser.  Two plaques were selected on each patient, and half of each plaque was treated with a single excimer laser dose, whereas the other half (control) was left untreated.  Eleven patients showed significant improvement with reduction of the plaque to a flat red macule within treated sites within one month.  There was no change in the control halves of the psoriatic plaques.  At baseline, the mean Psoriasis Area and Severity Index (PASI) score was 6.31, but 4 weeks after a single treatment the mean modified PASI score was 3.56 (p < 0.01).

Gerber et al (2003) reported on the effectiveness of the excimer laser in an uncontrolled study involving 120 patients with chronic plaque psoriasis; 102 of whom completed the study.  Patients were treated twice a week for the first 3 weeks, then once-weekly until clearance was achieved.  Of these patients, 2/3 had a 90 % or greater improvement in PASI score after a maximum of 10 treatments, and 85 % had 90 % or greater improvement in PASI score after a maximum of 13 sessions.  Blistering occurred at least once in 40 % of the patients, and 26 % in this group had erosions and pain.  Duration of remission was not reported.

Taneja et al (2003) reported on a before-and-after study of excimer laser therapy in 18 subjects with recalcitrant plaque psoriasis that had not responded to other treatments, 4 of whom dropped out before the end of the study.  Patients were treated twice-weekly.  A total of 44 plaques were treated with the excimer laser, and 1 lesion in each subject was left untreated as a control.  Plaques received a mean of 10 treatments (range of 4 to 14).  The mean PASI scores of the treated plaques decreased from 6.2 before treatment to 1.2 after 10 treatments, whereas the mean PASI scores of the untreated plaques increased from 6.4 before treatment to 6.9 after 10 treatments.  At follow-up, the mean modified PASI scores of all treated lesions gradually regressed from 1.0 at the time of the last treatment; to 2.0 by the end of the 3rd month; to 3.1 at the 6-month follow-up.  The relapse was mild in all cases and mostly focal in 20 of 44 cases.

Thus, the excimer laser may be considered as a treatment option for those patients in whom topical therapy has failed.  According to published clinical studies, responses increase with up to 13 treatments, and the typical duration of response is 4 to 6 months.  Additionally, clinical trials of the laser therapy selected patients with less than 10 % of body surface area affected because, in the clinical setting, it is not practical to treat more than 10 % of body surface area with the laser, because of the extended treatment time required due to the relatively small treatment spot size.

There is also adequate evidence that pulsed dye laser (PDL) is effective in the treatment of psoriasis (Ros et al, 1996; Zelickson et al, 1996; Lanigan et al, 1997; Taibjee et al, 2005; Erceg et al, 2006; Ilknur et al, 2006; de Leeuw et al, 2006; Bovenschen et al, 2007).  It should be noted that the National Psoriasis Foundation (2007) states that PDL can be used to treat chronic localized plaque lesions.

Ros et al (1996) used the flash-lamp-pumped PDL, which selectively damages dermal vessels, to treat psoriatic plaques and evaluated the role of the vasculature in the therapeutic response.  A total of 10 patients with psoriasis were treated with the PDL on single, stable psoriasis plaques.  Treatments varied between 1 and 3 times, and the lesional response was graded using a scale for erythema, scaling, and infiltration.  Six of 10 patients experienced a beneficial clinical effect after therapy.  The psoriasis severity scale in these patients was reduced to 2.2 +/- 1.3 compared with a 7.2 +/- 1.7 grade for control areas.  The plaques readily developed crusting with therapy, with 1 leg lesion healing with atrophy.  Histopathology in 3 patients immediately after therapy showed no epidermal damage.  One week after laser therapy, the necrotic former epidermis was apparent in superficial crusting.  Epidermal thinning and regeneration was seen without any signs of psoriasis.  The authors concluded that PDL therapy may improve plaque psoriasis; and this improvement may be related to the role the microvasculature plays in psoriasis.

Zelickson and co-workers (1996) examined the clinical and histological events of psoriasis treated with the PDL.  Psoriatic plaques were treated with a short (450 microseconds) and long (1,500 microseconds) pulse-width PDL.  Photographs of the plaques were used for clinical assessment.  Biopsy specimens were examined microscopically.  Significant clinical improvement was seen, and no significant difference between the short and long pulse-width PDL was observed.  Patients responding to treatment with the PDL remained in remission for up to 13 months.  Histological normalization occurred after treatment.  Two pre-treatment vascular patterns were seen:

1. vertically oriented vessels with few horizontal vessels, and
2. numerous tortuous vessels. 

Tortuous vessels were associated with poor clinical results.  The authors concluded that the PDL can induce prolonged remission in chronic plaque psoriasis; and the vascular pattern may help to distinguish those patients likely to respond to this treatment.

Taibjee and colleagues (2005) noted that the excimer laser delivers high energy monochromatic ultraviolet (UV) B at 308 nm.  Advantages over conventional UV sources include targeting of lesional skin, reducing cumulative dose and inducing faster clearance.  Studies of the PDL in psoriasis reported between 57 % and 82 % response rates; remission may extend to 15 months.  These investigators examined excimer laser and PDL in the treatment of psoriasis.  They conducted a within-patient controlled prospective trial of treatment of localized plaque psoriasis.  A total of 22 adult patients, mean PASI (mPASI) 7.1, were recruited.  Fifteen patients completed the full treatment, of which 13 were followed-up to 1 year.  Two selected plaques were treated with excimer twice-weekly and V Beam PDL, pre-treated with salicylic acid (SA), every 4 weeks, respectively.  Two additional plaques, treated with SA alone or untreated, served as controls.  The primary outcome measures were:

1. changes in plaque-modified Psoriasis Activity and Severity Index (PSI) scores from baseline to end of treatment;
2. clinical response to treatment (CR(T)), assessed by serial photographs;
3. percentage of plaques clear at the end of treatment; and
4. percentage of plaques clear at 1-year follow-up. 

The secondary outcome measures were:

1. number of laser treatments to clearance;
2. time to relapse;
3. frequency of side-effects; and
4. qualitative observations with SIAscope. 

The mean improvement in PSI was 4.7 (SD 2.1) with excimer and 2.7 (SD 2.4) with PDL.  PSI improvement was significantly greater in excimer than PDL (p = 0.003) or both control plaques (p < 0.001).  CR(T) indicated 13 patients responded best with excimer, 2 patients best with PDL, and in 7 patients there was no difference between the two lasers.  CR(T) was significantly greater for excimer than PDL (p = 0.003) or both controls (p < 0.001).  CR(T) was also significantly greater for PDL than SA alone (p = 0.004) or untreated control (p = 0.002).  Nine (41 %) patients cleared with excimer, after mean 8.7, median 10 weeks treatment.  Seven of these 9 patients were followed-up to 1 year; 4 remained clear, 2 relapsed at 1 month, and 1 at 6 months.  Six (27 %) patients cleared with PDL, after mean 3.3, median 4 treatments.  All 6 patients were followed-up to 1 year; 4 remained clear, 1 relapsed at 4 months and 1 at 9 months.  Despite common side-effects including blistering and hyper-pigmentation, patient satisfaction was high.  Serial images obtained with the SIAscope during treatment indicated different mechanisms of action of the two lasers.  The authors concluded that excimer and V Beam PDL are useful treatments for plaque psoriasis.  Although the excimer appears to be on average more effective, a subset of patients may respond better to PDL; and long-term remission is achievable with both lasers.

Erceg and colleagues (2006) compared the effectiveness of the PDL in the treatment of localized, recalcitrant plaque psoriasis with a potent topical therapy, using calcipotriol/betamethasone dipropionate (Dovobet) as an active comparator.  A total of 8 patients with psoriasis were treated with both PDL (585 nm) and calcipotriol/betamethasone dipropionate in an open, intra-patient, left-right comparison.  A plaque severity score (sum score) and photographs were used to document the course of therapy.  Patients reported pain on a visual analogue scale.  Both treatments were well- tolerated, although 1 patient left the study due to post-PDL treatment pain.  A significant difference in the sum score 12 weeks after treatment was seen in favor of the PDL (62 % versus 19 % reduction;  p < 0.05).  Scores for erythema declined significantly at week 12 in both the PDL and the calcipotriol/betamethasone dipropionate group (p < 0.001).  Induration and desquamation scores were significantly reduced at week 12 in the PDL group, without a statistically significant reduction in calcipotriol/betamethasone-treated lesions.  The pain scores declined with progressive PDL treatments, although not statistically significantly.  The authors concluded that PDL treatment might be considered for the treatment of localized, recalcitrant plaque psoriasis, when other topical therapies have failed.

Ilknur et al (2006) compared the effectiveness of the PDL treatment with that of clobetasol propionate treatment.  A total of 21 patients with chronic, stable psoriatic plaques that involved less than 20 % of their body were included in the study.  Three similar-appearing psoriasis plaques in these patients were selected.  Whereas the 1st plaque received only PDL, the 2nd plaque received PDL after salicylic acid, and the 3rd plaque received clobetasol propionate ointment and salicylic acid.  Evaluation of the study plaques was carried out by the mPASI score and by measuring the area of the plaques.  Of the 21 patients, 19 completed the study.  Although the decrease in mPASI scores was determined to be maximum for clobetasol propionate + salicylic acid-treated plaques and minimum for only PDL-treated plaques, the decrease was statistically significant in all groups when compared with baseline (p < 0.003).  At the 3- and 6-week evaluations, there was a statistically significant difference between clobetasol propionate + salicylic acid-treated plaques and the two PDL-treated plaques (p < 0.003); however, the difference observed at the 9-, 12-, and 15-week evaluations was statistically significant only between clobetasol propionate + salicylic acid-treated plaques and PDL-treated plaques (p < 0.003).  When the baseline and 15-week evaluations were compared, there was no statistically significant increase in the mean lesion areas of clobetasol propionate + salicylic acid-treated psoriatic plaques (p > 0.003), but there was a statistically significant increase in the mean lesion areas of two PDL-treated psoriatic plaques (p < 0.003).  The authors concluded that the results of this study showed that the effect of PDL could be increased when salicylic acid was added to treatment, although there was no statistically significant difference between both treatment protocols.  However, clobetasol propionate + salicylic acid treatment is more effective than both PDL and PDL + salicylic acid treatment.

de Leeuw et al (2006) prospectively assessed the safety and effectiveness of PDL treatment of psoriasis of the hands and feet.  A total of 41 patients with therapy-resistant psoriasis of the hands and feet were treated once every 4 to 6 weeks with PDL at 585-nm wavelength, 450-microsecond pulse duration, 7-mm spot diameter, and 5- to 6.5-J/cm2 fluence.  Calcipotriol ointment and salicylic acid 5 % to 10 % ointment were used as keratolytic agents.  Treatment effectiveness was evaluated by blinded comparison of photographs of the lesions taken before and after PDL treatment in each patient.  A good to very good improvement in the lesions was observed in 76 % of the patients after treatment.  An average duration of remission was 11 months.  Side effects were transient purpura, moderate discomfort during the treatment, transient hyper-pigmentation or hypo-pigmentation, and incidental transient crustae.  The authors concluded that concomitant treatment with PDL and topical calcipotriol, salicylic acid, or both was a satisfactory modality for treating psoriasis of the hands and feet.  There was a subjective improvement in the symptoms and quality of life in all patients.

Bovenschen and colleagues (2007) reported that after 8 weeks of follow-up, PDL treatment for localized and recalcitrant plaque psoriasis resulted in persistent reductions of activated and memory effector T-helper cells in the dermis, cytotoxic T cells in the epidermis, and normalization of epidermal proliferation and keratinization, in contrast to treatment with calcipotriol/betamethasone dipropionate ointment.

In summary, direct comparative studies have shown the excimer laser to be more effective than the pulsed dye laser for psoriasis (Taibjee et al, 2005).  However, the pulsed dyle laser requires fewer treatments and has fewer side effects.  The pulsed dye laser target a different part of the psoriasis pathway than the excimer laser, with the pulsed dye laser targeting the abnormal microvasculature of psoriatic plaques.  Because of its different target, it has been suggested that the pulsed dye laser may be useful in excimer-laser–resistant cases (Hruza, 2005), as some patients who do not respond to the excimer laser have been shown to respond to the pulsed dye laser.

De Leeuw et al (2009) compared the results of PDL with UVB and looked for synergism of both therapies in patients with plaque type psoriasis.  In each eligible individual, 4 similar target plaques were selected, and halves of these plaques were treated using PDL, UVB, or a combination of PDL and UVB or were not treated.  Results were recorded single-blind using the Physician's Global Assessment score at study enrolment and week 13.  Non-parametric, paired statistical tests were used to test for differences within and between therapies.  The results were also analyzed after dichotomization of the changes in the Physician's Global Assessment score into responsive and non-responsive to treatment.  A significant improvement of the psoriasis lesions was noted at week 13 (p < 0.001) with each therapy.  No significant differences were noted between the therapies.  Synergism of PDL and UVB was not observed.  The authors concluded that PDL is safe for treating plaque type psoriasis, but its effectiveness is limited to a subgroup of patients.  They noted that combining PDL with UVB has no additional benefit.

Gattu and colleagues (2009) stated that the 308-nm excimer laser is a recent development in the treatment of psoriasis vulgaris, palmoplantar psoriasis, and psoriasis of the scalp.  These researchers reviewed recent updates on the effectiveness of excimer laser and its most recent trials in psoriasis.  A review of the medical literature in PubMed database was performed using the terms "psoriasis" and "308 nm excimer laser".  All trials to date that studied the 308-nm excimer including those that compared the excimer with other modalities were included.  A total of 18 trials showed positive results surrounding the effectiveness of the excimer laser.  Selectivity of the 308-nm excimer laser, when compared with non-selective narrow-band UVB (NB-UVB) phototherapy allows one to adjust the fluency to the lesion.  The excimer laser may also stand superior to NB-UVB in its efficacy of mechanism.  The authors concluded that excimer laser is a useful and effective treatment for psoriasis that may be used as a compliment to topical medications as well as NB-UVB.  However, lthey stated that large randomized trials with long-term follow-up are needed to further support this.

Hidradenitis Suppurativa

Krakowski et al (2014) stated that hidradenitis suppurativa (HS) is a chronic, relapsing, inflammatory skin condition that can have a significant psychosocial impact, both with the active disease and with residual scarring.  Although a wide variety of treatment options exist for HS, there are no reported modalities aimed specifically at treating HS scarring.  These researchers described the case of an adolescent female who received medical management of intra-mammary HS followed by successful treatment with fractionated 10,600-nm carbon dioxide (CO2) laser for her residual cribriform scarring.  The authors believed there is great potential for the use of fractionated CO2 laser to improve short- and long-term psychosocial outcomes of HS, promote physical scar remodeling, and possibly alter the disease process itself.

Lichen Sclerosus

The Royal College of Obstetricians and Gynaecologists' clinical practice guideline on "The management of vulval skin disorders" (RCOG, 2001) stated that "surgery and CO2 laser vaporisation are not recommended for the treatment of symptoms of lichen sclerosus".

Melasma

In a randomized, controlled, observer-blinded, split-face clinical study, Wind et al (2010) evaluated the safety and effectiveness of non-ablative 1,550 nm fractional laser therapy (FLT) as compared to the gold standard, triple topical therapy (TTT) for the treatment of melasma.  A total of 29 patients were included in the study.  Each side of the face was randomly allocated to either 4 to 5 non-ablative FLT sessions (15 mJ/microbeam, 14 to 20 % coverage) or TTT (hydroquinone 5 %, tretinoin 0.05 %, and triamcinolone acetonide 0.1 % cream).  Triple topical therapy was applied once-daily for 15 weeks until the last FLT session.  After this last treatment, patients were asked to apply TTT twice-weekly on both sides of the face during follow-up.  Improvement of melasma was assessed by patient's global assessment (PGA), patient's satisfaction, physician's global assessment (PhGA), melanin index, and lightness (L-value) at 3 weeks, and at 3 and 6 months after the last treatment.  Mean PGA and satisfaction were significantly lower at the FLT side (p < 0.001).  Melanin index, PhGA and L-value showed a significant worsening of hyperpigmentation at the FLT side.  At the TTT side, no significant change was observed.  At 6 months follow-up, most patients preferred TTT.  Side effects of FLT were erythema, burning sensation, edema, and pain.  Nine patients (31 %) developed post-inflammatory hyperpigmentation after 2 or more laser sessions.  Side effects of TTT were erythema, burning sensation, and scaling.  The authors concluded that given the high rate of post-inflammatory hyperpigmentation, non-ablative 1,550 nm fractional laser at 15 mJ/microbeam is not recommendable in the treatment of melasma; TTT remains the gold standard treatment.

Mycosis Fungoides

UpToDate reviews on "Treatment of early stage (IA to IIA) mycosis fungoides" (Hoppe and Kim, 2012a) and "Treatment of advanced stage (IIB to IV) mycosis fungoides and Sezary syndrome" (Hoppe and Kim, 2012b) do not mention the use of laser.

Onychomycosis

Landsman et al (2010) stated that the Noveon is a unique dual-wavelength near-infrared diode laser used to treat onychomycosis.  The device operates at physiologic temperatures that are thermally safe for human tissue.  It uses only 870- and 930-nm near-infrared light, wavelengths that have unique photo-lethal effects on fungal pathogens.  These wavelengths lack the teratogenic danger presented by UV light and the photo-ablation toxic plume associated with pulsed neodymium-doped:yttrium aluminum garnet (Nd:YAG) lasers.  In this randomized, controlled study, treatments followed a pre-defined protocol and laser parameters and occurred on days 1, 14, 42, and 120.  Toes were cultured and evaluated, and measurements were taken from standardized photographs obtained periodically during the 180 day follow-up period.  These researchers treated mycologically confirmed onychomycosis in 26 eligible toes (10 mild, 7 moderate, and 9 severe).  All of the patients were followed-up for 180 days.  An independent expert panel, blinded regarding treatment versus control, found that at 180 days, 85 % of the eligible treated toenails were improved by clear nail linear extent (p = 0.0015); 65 % showed at least 3 mm and 26 % showed at least 4 mm of clear nail growth.  Of the 16 toes with moderate-to-severe involvement, 10 (63 %) improved, as shown by clear nail growth of at least 3 mm (p = 0.0112).  Simultaneous negative culture and periodic acid-Schiff was noted in 30 % at 180 days.  The authors concluded that these results indicated a role for this laser in the treatment of onychomycosis, regardless of degree of severity.  Ease of delivery and the lack of a need to monitor blood chemistry are attractive attributes.  Drawbacks of this study were its' small sample size and short-term follow-up.

Hochman et al (2011) evaluated the treatment of onychomycosis using a novel 0.65-millisecond (ms) pulsed 1,064-nm laser.  A total of 8 subjects were treated over 2 to 3 sessions spaced at least 3 weeks apart.  Of the 8 subjects evaluated, 7 had negative post-treatment cultures after the 2nd or 3rd session.  Treatments were well-tolerated by all subjects.  These data suggested that treatment of onychomycosis with a 0.65-ms pulsed Nd:YAG 1,064-nm laser should be studied further to determine the long-term clinical and microbiologic effect.  The optimal number of treatment sessions for each patient needs to be determined.

A report by the National Horizon Scanning Centre (2011) on laser treatment of onychomycosis concluded: "Randomised controlled trials of infrared treatment are needed to determine the safety and effectiveness of this type of therapy for onychomycosis.  Long-term studies are also necessary to investigate recurrence.  Comparative studies of these three devices with alternative therapies, and with each other, would help determine the most effective type of treatment for this condition".

Ortiz et al (2014) performed a literature search on laser and light-based treatments for onychomycosis.  Early data are promising, however, many of these studies are small or poorly designed.  The authors concluded that further evaluation and larger studies are needed to determine the optimal light source, pulse duration, and treatment schedule for long-term success.

Nenoff et al (2014) noted that since 2010 the Food and Drug Administration (FDA) has approved laser systems as capable of producing a "temporary increase in clear nails" in patients with onychomycosis.  Fungal eradication is probably mediated by heat in infrared laser systems; their efficacy has been confirmed thermographically, histologically and in electron microscopy.  Another approach to decontaminate the nail organ is to disrupt fungi and spores by q-switched pulse applications.  Recently specific combinations of wavelengths have been tested for their ability to disrupt the mitochondrial transmembrane potential at physiological temperatures by generating ATP and ROS.  While clinically extremely high clearance rates of approximately 87.5 to 95.8 % have been reported, in-vitro investigations have failed to confirm the clearance.  The variety of systems and advised parameters hampers a systematic evaluation.  Recommendations for safe and practical treatment protocols, informed consent items, and combination with conventional treatment options are all areas of active work.  The authors concluded that currently there is a lack of data concerning the long-term effectiveness of laser therapy of onychomycosis; certified treatment protocols are needed.

Pilonidal Sinus Disease

Lukish et al (2009) the use of laser epilation (LE) of the inter-gluteal hair in adolescents with pilonidal disease (PD) as a method of permanent hair removal.  A retrospective review of all patients with PD who underwent LE from 2003 to 2006 at the National Naval Medical Center (Bethesda, MD) and Walter Reed Army Medical Center, (Washington, DC) was performed.  Laser epilation of the inter-gluteal hair was performed with a 1064 nm Nd:YAG laser (Coolglide Vantage, Altus/Cutera, Brisbane, CA) at a standard fluence (joule/square centimeter), pulse duration, and repetition rate based on skin phototype.  Patients were observed for hair regrowth and recurrence.  A total of 28 teenagers (17 males, 11 females; mean age of 17.2 +/- 1.4 years) underwent LE.  Eight patients presented with abscess and were managed by incision and drainage followed by excision and open wound management, 17 patients presented with a cyst or sinus and underwent excision and primary closure, and 3 patients with asymptomatic sinus were managed non-operatively.  Laser epilation was performed after complete wound healing or immediately in those patients with asymptomatic sinus disease.  Laser epilation was well-tolerated and without complication in all patients.  Inter-gluteal hair was completely removed in all patients.  Patients required an average of 5 +/- 2 LE therapy sessions for hair removal.  All patients underwent at least 3 LE sessions (range of 3 to 7 sessions) at 4-week intervals.  One female developed a recurrence.  The mean follow-up for the group was 24.2 +/- 9.9 months.  The authors concluded that laser epilation is a safe method to remove inter-gluteal hair in teenagers with PD.  This technique is an effective adjunctive therapy for the treatment of PD that may reduce recurrence. The drawbacks of this study included a small sample size and lack of a control group.

Petersen et al (2009) examined the potential benefits of post-operative epilation after pilonidal sinus surgery, and the long-term effect of hair removal on pilonidal recurrence .  The authors stated that razor hair removal increases the rate of long-term recurrence after surgery for pilonidal sinus disease and therefore should not be recommended.  However, the rationale for hair removal in pilonidal sinus disease is compelling.  Other epilation techniques such as laser hair removal should be investigated in appropriate studies.

Oram and colleagues (2010) evaluated the role of alexandrite laser hair removal after surgery in the treatment of patients with  pilonidal sinus disease.  A total of 60 patients who underwent surgical treatment of pilonidal sinus disease and were treated with a 755-nm alexandrite laser after surgery between 1999 and 2007 were examined retrospectively.  The charts were reviewed, and the patients were interviewed on the telephone about their post-laser period and recurrence.  The laser parameters, patient history, and surgical details were recorded.  The overall recurrence rate was 13.3 %, after a mean follow-up period +/- standard error of the mean of 4.8 +/- 0.3 years.  The mean number of laser treatment was 2.7 +/- 0.1.  Seventy-five percent of the recurrences were detected after a follow-up period of 5 to 9 years.  Fifty percent of the recurrent cases had drainage and secondary intention before the laser epilation.  The authors concluded that these findings suggested that laser hair removal after surgical interventions in pilonidal sinus disease decreases the risk of recurrence over the long-term.  This study had no control group, which limits the validity of the study’s conclusion.

There is insufficient evidence to conclude that laser hair removal is effective for treating pilonidal sinus disease.  Most of the studies regarding this treatment were small and uncontrolled.  Well-designed studies are needed to determine the effectiveness of laser hair removal for this condition.

Prurigo Nodularis

Saraceno et al (2008) stated that 308 nm excimer light has been reported to be safe and effective in the treatment of chronic skin diseases, but the range of potential applications has not been fully explored.  These researchers evaluated the effectiveness of monochromatic excimer light (MEL) in the treatment of prurigo nodularis.  A total of 11 patients were enrolled in this pilot study.  Patients were treated weekly and an average of 8 sessions of MEL was given.  Follow-up was 4 months.  Partial or complete clinical and histological remission was observed in all patients who completed the study (81 %).

Spongiotic Dermatitis

Spongiotic dermatitis is another way of referring to a condition known as acute eczema that is usually found affecting the abdomen, chest and even the bottom while the scalp is generally free from this condition.  An UpToDate review on “Treatment of atopic dermatitis (eczema)” (Weston and Howe, 2014) does not mention the use of laser as a therapeutic option.  In fact, a study by Levine and Geronemus (1995) reported spongiotic dermatitis as a side effect following PDL therapy.  These investigators assessed the incidence of adverse effects associated with the use of the PDL in the treatment of vascular lesions.  They studied 500 patients undergoing PDL treatments for port-wine stains, telangiectases, and hemangiomas.  All patients were examined during the course of their treatment to assess the incidence of adverse effects associated with the use of the PDL.  There were no cases of hypertrophic scarring.  The incidence of atrophic scarring was less than 0.1 %.  Moreover, spongiotic dermatitis was seen in 11 of 297 patients (4 %) after multiple treatments of port-wine stains.  Hyper-pigmentation was seen in 5 of 500 patients (1 %), whereas transient hypo-pigmentation was seen in 13 (2.6 %).

Vulval Intraepithelial Neoplasia

Vulval intraepithelial neoplasia (VIN) is a pre-malignant condition of the vulval skin.  This uncommon chronic skin condition of the vulva is associated with a high-risk of recurrence and the potential to progress to vulval cancer.  The condition is complicated by its' multi-centric and multi-focal nature.  There is a lack of consensus on the optimal surgical treatment method.  However, the rationale for surgical treatment of VIN has been to treat symptoms and exclude underlying malignancy with the continued aim of preservation of vulval anatomy and function.  Repeated treatments affect local cosmesis and cause psychosexual morbidity, thus impacting on the patients' quality of life (Kaushik et al, 2011).

In a Cochrane review, Kaushik and colleagues (2011) evaluated the effectiveness and safety of surgical interventions for high-grade VIN.  These investigators searched the Cochrane Central Register of Controlled Trials (CENTRAL), Issue 3, 2010, Cochrane Gynaecological Cancer Group Trials Register, MEDLINE and EMBASE up to September 2010.  They also searched registers of clinical trials, abstracts of scientific meetings, reference lists of included studies and contacted experts in the field.  Randomized controlled trials (RCTs) that compared surgical interventions, in adult women diagnosed with high-grade VIN.  Two review authors independently abstracted data and assessed risk of bias.  They found only 1 RCT, which included 30 women that met inclusion criteria and this trial reported data on carbon dioxide laser (CO(2) laser) versus ultrasonic surgical aspiration (USA). There was no statistically significant difference in the risk of disease recurrence after 1 year follow-up, pain, presence of scarring, dysuria or burning, adhesions, infection, abnormal discharge and eschar between women who received CO(2) laser and those who received USA.  The trial lacked statistical power due to the small number of women in each group and the low number of observed events, but was at low-risk of bias.  The authors concluded that the included trial lacked statistical power due to the small number of women in each group and the low number of observed events.  Thus, in the absence of reliable evidence regarding the effectiveness and safety of the 2 surgical techniques for the management of VIN precludes any definitive guidance or recommendations for clinical practice.

Acne Scars

In a Cochrane review, Abdel et al (2016) evaluated the effects of interventions for treating acne scars. These investigators searched the following databases up to November 2015: the Cochrane Skin Group Specialised Register, the Cochrane Central Register of Controlled Trials (CENTRAL) in the Cochrane Library (2015, Issue 10), MEDLINE (from 1946), EMBASE (from 1974), and LILACS (from 1982).  They also searched 5 trials registers, and checked the reference lists of included studies and relevant reviews for further references to RCTs.  These researchers included RCTs that allocated participants (whether split-face or parallel arms) to any active intervention (or a combination) for treating acne scars.  They excluded studies dealing only or mostly with keloid scars.  Three review authors independently extracted data from each of the studies included in this review and evaluated the risks of bias.  They resolved disagreements by discussion and arbitration supported by a method expert as required.  The primary outcomes were participant-reported scar improvement and any adverse effects serious enough to cause participants to withdraw from the study.  The authors included 24 trials with 789 adult participants aged 18 years or older; 20 trials enrolled men and women, 3 trials enrolled only women and 1 trial enrolled only men.  These investigators judged 8 studies to be at low risk of bias for both sequence generation and allocation concealment.  With regard to blinding the authors judged 17 studies to be at high risk of performance bias, because the participants and dermatologists were not blinded to the treatments administered or received; however, the authors judged all 24 trials to be at a low risk of detection bias for outcome assessment.  They evaluated 14 comparisons of 7 interventions and 4 combinations of interventions; 9 studies provided no usable data on the outcomes and did not contribute further to this review's results.  For the outcome “Participant-reported scar improvement” in 1 study, fractional laser was more effective in producing scar improvement than non-fractional non-ablative laser at week 24 (risk ratio (RR) 4.00, 95 % confidence interval (CI): 1.25 to 12.84; n = 64; very low-quality evidence); fractional laser showed comparable scar improvement to fractional radiofrequency in 1 study at week 8 (RR 0.78, 95 % CI: 0.36 to 1.68; n = 40; very low-quality evidence) and was comparable to combined chemical peeling with skin needling in a different study at week 48 (RR 1.00, 95 % CI: 0.60 to 1.67; n = 26; very low-quality evidence).  In a further study chemical peeling showed comparable scar improvement to combined chemical peeling with skin needling at week 32 (RR 1.24, 95 % CI: 0.87 to 1.75; n = 20; very low-quality evidence).  Chemical peeling in 1 study showed comparable scar improvement to skin needling at week 4 (RR 1.13, 95 % CI: 0.69 to 1.83; n = 27; very low-quality evidence).  In another study, injectable fillers provided better scar improvement compared to placebo at week 24 (RR 1.84, 95 % CI: 1.31 to 2.59; n = 147 moderate-quality evidence).  For the outcome “Serious adverse effects” in 1 study, chemical peeling was not tolerable in 7/43 (16 %) participants (RR 5.45, 95 % CI: 0.33 to 90.14; n = 58; very low-quality evidence).  For the secondary outcome “Participant-reported short-term adverse events”, all participants reported pain in the following studies: in 1 study comparing fractional laser to non-fractional non-ablative laser (RR 1.00, 95 % CI: 0.94 to 1.06; n = 64; very low-quality evidence); in another study comparing fractional laser to combined peeling plus needling (RR 1.00, 95 % CI: 0.86 to 1.16; n = 25; very low-quality evidence); in a study comparing chemical peeling plus needling to chemical peeling (RR 1.00, 95 % CI: 0.83 to 1.20; n = 20; very low-quality evidence); in a study comparing chemical peeling to skin needling (RR 1.00, 95 % CI: 0.87 to 1.15; n = 27; very low-quality evidence); and also in a study comparing injectable filler and placebo (RR 1.03, 95 % CI: 0.10 to 11.10; n = 147; low-quality evidence).  For the outcome “Investigator-assessed short-term adverse events”, fractional laser (6/32) was associated with a reduced risk of hyper-pigmentation than non-fractional non-ablative laser (10/32) in 1 study (RR 0.60, 95 % CI: 0.25 to 1.45; n = 64; very low-quality evidence); chemical peeling was associated with increased risk of hyper-pigmentation (6/12) compared to skin needling (0/15) in 1 study (RR 16.00, 95 % CI: 0.99 to 258.36; n = 27; low-quality evidence).  There was no difference in the reported adverse events with injectable filler (17/97) compared to placebo (13/50) (RR 0.67, 95 % CI: 0.36 to 1.27; n = 147; low-quality evidence).  The authors concluded that there is a lack of high-quality evidence about the effects of different interventions for treating acne scars because of poor methodology, under-powered studies, lack of standardized improvement assessments, and different baseline variables.  There is moderate-quality evidence that injectable filler might be effective for treating atrophic acne scars; however, no studies have assessed long-term effects, the longest follow-up being 48 weeks in 1 study only.  Other studies included active comparators, but in the absence of studies that establish efficacy compared to placebo or sham interventions, it is possible that finding no evidence of difference between 2 active treatments could mean that neither approach works.  The authors stated that the findings of this review did not provide support for the 1st-line use of any intervention in the treatment of acne scars.  They noted that although their aim was to identify important gaps for further primary research, it might be that placebo and or sham trials are needed to establish whether any of the active treatments produce meaningful patient benefits over the long-term.

Herpes Simplex Labialis

Chi and associates (2015) noted that herpes simplex labialis (HSL), also known as cold sores, is a common disease of the lips caused by the herpes simplex virus (HSV), which is found throughout the world. In a Cochrane review, these researchers evaluated the effects of interventions for the prevention of HSL in people of all ages.  They searched the following databases up to May 19, 2015: the Cochrane Skin Group Specialised Register, the Oral Health Group Specialised Register, CENTRAL in the Cochrane Library (Issue 4, 2015), Medline (from 1946), Embase (from 1974), LILACS (from 1982), the China National Knowledge Infrastructure (CNKI) database, Airiti Library, and 5 trial registers.  To identify further references to relevant RCTs, these investigators scanned the bibliographies of included studies and published reviews, and they also contacted the original researchers of the included studies.  Randomized controlled trials of interventions for preventing HSL in immunocompetent people were selected for analysis.  Two authors independently selected trials, extracted data, and assessed the risk of bias; a 3rd author was available for resolving differences of opinion.  This review included 32 RCTs, with a total of 2,640 immunocompetent participants, covering 19 treatments.  The quality of the body of evidence was low-to-moderate for most outcomes, but was very low for a few outcomes.  The primary outcomes were “Incidence of HSL” and “Adverse effects during use of the preventative intervention”.  The evidence for short-term (less than or equal to 1 month) use of oral aciclovir in preventing recurrent HSL was inconsistent across the doses used in the studies: 2 RCTs showed low quality evidence for a reduced recurrence of HSL with aciclovir 400-mg twice-daily (RR 0.26, 95 % CI: 0.13 to 0.51; n = 177), while 1 RCT testing aciclovir 800-mg twice-daily and 2 RCTs testing 200-mg 5 times daily found no similar preventive effects (RR 1.08, 95 % CI: 0.62 to 1.87; n = 237; moderate quality evidence and RR 0.46, 95 % CI: 0.20 to 1.07; n = 66; low quality evidence, respectively).  The direction of intervention effect was unrelated to the risk of bias.  The evidence from 1 RCT for the effect of short-term use of valaciclovir in reducing recurrence of HSL by clinical evaluation was uncertain (RR 0.55, 95 % CI: 0.23 to 1.28; n = 125; moderate quality evidence), as was the evidence from 1 RCT testing short-term use of famciclovir.  Long-term (greater than 1 month) use of oral antiviral agents reduced the recurrence of HSL.  There was low quality evidence from 1 RCT that long-term use of oral aciclovir reduced clinical recurrences (1.80 versus 0.85 episodes per participant per a 4-month period, p = 0.009) and virological recurrence (1.40 versus 0.40 episodes per participant per a 4-month period, p = 0.003).  One RCT found long-term use of valaciclovir effective in reducing the incidence of HSL (with a decrease of 0.09 episodes per participant per month; n = 95).  One RCT found that a long-term suppressive regimen of valaciclovir had a lower incidence of HSL than an episodic regimen of valciclovir (difference in means (MD) -0.10 episodes per participant per month, 95 % CI: -0.16 to -0.05; n = 120).  These trials found no increase in adverse events associated with the use of oral anti-viral agents (moderate quality evidence).  There was no evidence to show that short-term use of topical antiviral agents prevented recurrent HSL.  There was moderate quality evidence from 2 RCTs that topical aciclovir 5 % cream probably has little effect on preventing recurrence of HSL (pooled RR 0.91, 95 % CI: 0.48 to 1.72; n = 271).  There was moderate quality evidence from a single RCT that topical foscarnet 3 % cream has little effect in preventing HSL (RR 1.08, 95 % CI: 0.82 to 1.40; n = 295).  The effectiveness of long-term use of topical aciclovir cream was uncertain.  One RCT found significantly fewer research-diagnosed recurrences of HSL when on aciclovir cream treatment than on placebo (p < 0.05), but found no significant differences in the mean number of participant-reported recurrences between the 2 groups (p ≥ 0.05).  One RCT found no preventive effect of topical application of 1,5-pentanediol gel for 26 weeks (p > 0.05).  Another RCT found that the group who used 2-hydroxypropyl-β-cyclo dextrin 20 % gel for 6 months had significantly more recurrences than the placebo group (p = 0.003).  These studies found no increase in adverse events related to the use of topical anti-viral agents.  Two RCTs found that the application of sunscreen significantly prevented recurrent HSL induced by experimental UV light (pooled RR 0.07, 95 % CI: 0.01 to 0.33; n = 111), but another RCT found that sunscreen did not prevent HSL induced by sunlight (RR 1.13, 95 % CI: 0.25 to 5.06; n = 51).  These RCTs did not report adverse events.  There were very few data suggesting that thymopentin, low-level laser therapy, and hypnotherapy are effective in preventing recurrent HSL, with 1 to 2 RCTs for each intervention.  These researchers failed to find any evidence of effectiveness for lysine, LongoVital supplementation, gamma globulin, HSV type I subunit vaccine, and yellow fever vaccine in preventing HSL.  There were no consistent data supporting the effectiveness of levamisole and interferon, which were also associated with an increased risk of adverse effects such as fever.  The authors concluded that the current evidence demonstrated that long-term use of oral anti-viral agents can prevent HSL, but the clinical benefit is small.  These investigators did not find evidence of an increased risk of adverse events.  On the other hand, the evidence on topical anti-viral agents and other interventions either showed no effectiveness or could not confirm their effectiveness in preventing HSL.

Other Indications

Erceg and colleagues (2013) systematically reviewed all available literature concerning PDL treatment for inflammatory skin diseases and proposed a recommendation.  These investigators searched for publications dated between January 1992 and August 2011 in the database PubMed.  All studies reporting on PDL treatment for an inflammatory skin disease were obtained and a level of evidence was determined.  Literature search revealed 52 articles that could be included in this study.  The inflammatory skin diseases treated with PDL consisted of: psoriasis, acne vulgaris, lupus erythematodes, granuloma faciale, sarcoidosis, eczematous lesions, papulopustular rosacea, lichen sclerosis, granuloma annulare, Jessner lymphocytic infiltration of the skin, and reticular erythematous mucinosis.  The effectiveness of PDL laser treatment for these inflammatory skin diseases was described and evaluated.  However, most conclusions formulated were not based on RCTs.  The authors concluded that PDL treatment can be recommended as an effective and safe treatment for localized plaque psoriasis and acne vulgaris (recommendation grade B).  However, for all other described inflammatory skin diseases, PDL appeared to be promising, although the level of recommendation did not exceed level C.

Granuloma Annulare

Verne and colleagues (2016) noted that granuloma annulare (GA) is a benign asymptomatic dermatosis that typically manifests in papules arrayed in annular arrangements.  Many methods of treatment have been used with variable degrees of success, but finding a consistent and long-term treatment has proven a challenge.  These researchers evaluated the latest published research on the use of lasers in the treatment of GA.  They carried out a systematic search of the National Library of Medicine's PubMed database to identify relevant articles; 7 reports met the inclusion criteria for the review.  Evidence for the use of PDL, fractional photothermolysis, and Excimer laser in the treatment of GA was found.  Findings were limited by a lack of well-designed clinical trials objectively evaluating the use of lasers in the treatment of GA.  The literature review found a number of case reports and case series that reported successful outcomes of the use of lasers in the treatment of GA.  The authors concluded that the promising results reported in the literature, coupled with the lack of a well-designed review on this topic, reflect the importance of this article to the dermatologic literature as it emphasized the need for larger and better-designed studies on the use of lasers to treat GA.

Facial Warts (Verrucae)

Maranda and colleagues (2016) noted that facial verruca plana, or flat warts, are benign skin papillomas caused by human papillomavirus (HPV) infections.  A large portion of cases are refractory to treatment and can cause psychosocial distress in patients.  Laser and light modalities offer an alternative therapeutic approach that has not been extensively explored.  These investigators systematically reviewed PubMed for studies describing treatment of facial verruca plana using lasers, photodynamic therapy (PDT) and infrared coagulation.  Final inclusion and review of 18 studies suggested laser and light therapies to have considerable potential in the treatment of this recalcitrant condition.  In particular, yttrium aluminum garnet lasers, infrared coagulation and photodynamic therapies have been reported to demonstrate efficacy.  The authors concluded that further studies with larger power are needed to determine which method should be established as the alternative treatment of choice for recalcitrant facial verrucae.

Keratosis Pilaris

Vachiramon and associates (2016) stated that keratosis pilaris (KP) is a common condition that can often be cosmetically disturbing.  Topical treatments can be used with limited effectiveness.  In a prospective, randomized, single-blinded, intra-individual, comparative study, these investigators evaluated the safety and effectiveness of fractional CO2 laser for the treatment of KP.  This trial was conducted on adult patients with KP.  A single session of fractional CO2 laser was performed to one side of arm whereas the contralateral side served as control.  Patients were scheduled for follow-up at 4 and 12 weeks after treatment.  Clinical improvement was graded subjectively by blinded dermatologists.  Patients rated treatment satisfaction at the end of the study.  A total of 20 patients completed the study.  All patients stated that the laser treatment improved KP lesions.  At 12-week follow-up, 30 % of lesions on the laser-treated side had moderate-to-good improvement according to physicians' global assessment (p = 0.02).  Keratotic papules and hyper-pigmentation appeared to respond better than the erythematous component; 4 patients with Fitzpatrick skin type V developed transient pigmentary alteration.  The authors concluded that fractional CO2 laser treatment may be offered to patients with KP; dark-skinned patients should be treated with special caution.  They stated that further studies are needed to find the optimum parameter, appropriate frequency, and suitable treatment sessions of fractional CO2 laser for KP.

The main drawbacks of this study were the small sample size and the short follow-up time of 3 months.  Thus, a conclusion cannot be drawn as to how long the laser effect would last and whether recurrence would occur.  Moreover, these researchers did not count the actual keratotic lesions and skin roughness was inaccessible through the evaluation by 2D photography.  Finally, this study was performed in Asian subjects with Fitzpatrick skin types III to V; hence, this laser setting cannot be applied to all skin types.

Maghfour et al (2022) stated that KP is a common, benign skin condition of follicular hyperkeratosis.  Although KP is asymptomatic, the cosmetic appearance of KP can lead to psychosocial distress among patients.  New emerging treatments are increasingly being utilized; however, there is little to no summative data on the treatments of KP and its subtypes.  In a systematic review, these investigators summarized existing literature on the treatments of KP and its subtypes.  They carried out a comprehensive search using PubMed/Medline, Embase and Web of Science databases.  The search identified 1,150 non-duplicated articles, and 47 studies were included in the review.  The primary outcomes measured were KP treatment type and the degree of improvement following therapy.  The findings showed that the most supported form of treatment for KP is laser therapy, especially the QS:Nd YAG laser.  Topical treatments, including Mineral Oil-Hydrophil Petrolat, tacrolimus, azelaic acid, and salicylic acid, are also effective at least for improving the appearance of KP.  The authors concluded that while the measured treatment outcomes varied among studies, laser therapy appeared to be the most effective form of treatment; and use of topicals also improved KP lesions.

The authors stated that drawbacks of this review included heterogeneity among studies in terms of methods, design, and quality.  While most studies were designed as cohort, pilot, and randomized controls, data were also extracted from individual studies.  Furthermore, there was a significant heterogeneity in the assessment tools used to measure the degree of severity and improvement following KP treatment.

Suastegui-Rodriguez et al (2022) noted that KP is a common dermatosis observed in daily dermatologic practice.  The diagnosis is clinical and usually asymptomatic, although sometimes patients may complain of mild pruritus and its cosmetic appearance.  Few reports exist regarding its treatment.  There were clinical trials examining topical treatments and laser surgery; however, no systematic reviews on its management were found in literature.  These investigators carried out an online research to identify evidence-based recommendations.  Lactic acid, salicylic acid, and the 1064-nm Nd:YAG laser appeared to be the most effective and safe therapeutic options for KP among patients aged 12 years and older; however, high-quality RCTs with long-term outcomes are needed.

Necrobiotic Xanthogranuloma

Miguel and colleagues (2017) stated that necrobiotic xanthogranuloma (NXG) is an uncommon non-Langerhans cell histiocytosis involving skin and extra-cutaneous tissues.  The lesions are usually asymptomatic and commonly appear in the peri-orbital area.  Paraproteinemia is closely associated with NXG and its pathogenesis remains unclear.  NXG prognosis is poor with several treatments showing variable results.  Treatment of monoclonal gammopathy with alkylating agents does not necessarily influence the activity of the skin disease and vice versa.  These researchers summarized all reported treatments of NXG of the skin, with or without underlying malignant condition and based on articles from the PubMed database using the query 'necrobiotic xanthogranuloma treatment', both in English and German, about 'human' subjects and published between 1980 and 2014, documenting adequate treatment for NXG.  Mainly individual case reports, small case series and retrospective studies were found.  Therapeutic options include topical and systemic corticosteroids, thalidomide, high-dose intravenous immunoglobulin (IVIG), chlorambucil, cyclophosphamide, fludarabine, rituximab, melphalan, infliximab, interferon alpha, cladribine, hydroxychloroquine, azathioprine, methotrexate, laser therapy, radiotherapy, surgery, PUVA, plasmapheresis and extracorporeal photopheresis.  The authors concluded that RCTS and studies on long-term outcomes after treatment were not found and are needed to focus on in the future.

Pearly Penile Papules

Maranda and associates (2017) stated that pearly penile papules (PPP) present as dome-shaped papules of no more than 3 mm in diameter that line the base of the glans of the penis.  These benign lesions affect between 14.3 and 48 % of men.  While often asymptomatic, PPP can cause a great deal of psychological distress that may warrant treatment.  Current treatment options include cryotherapy, electrodessication, and curettage (ED&C).  However, these modalities may have considerable adverse cosmetic effects, including scarring, pain, and pigmentary changes.  Laser modalities offer clear potential for improved cosmetic outcome in PPP treatment, but is not routinely used.  These researchers carried out a systematic review of available literature using the National Library of Medicine database PubMed to find articles relevant to the treatment of PPP with laser and light therapy.  The systematic search and screening of articles resulted in inclusion of 8 articles discussing a total of 55 patients with PPP treated by laser therapy.  The present systematic review found that erbium:yttrium-aluminum-garnet (Er:YAG) and CO2 laser were the most commonly reported (n = 45 and 7, respectively).  Furthermore, the use of CO2, Er:YAG, pulsed dye laser, and fractional photothermolysis therapies demonstrated complete clearance of PPP in all cases with minimal complications and discomfort.  Thus, based on the currently available evidence, laser therapy is a well-tolerated and effective method for treating PPP with minimal long-term adverse events (AEs) and a cosmetically desirable outcome.  The authors concluded that although the included studies are limited in power, this systematic review offered clinically relevant insight into the potential for laser therapy.

Rhinophyma

Kraeva and colleagues (2016) noted that rhinophyma, a late complication of rosacea, is a chronic, progressive dermatological condition.  The classic presentation of rhinophyma is nodular, thickened skin over the distal nose, and is often accompanied by underlying erythema secondary to inflammation.  Due to the unpleasant esthetic and disfiguring appearance, rhinophyma may be associated with a significant negative psychosocial impact, resulting in decreased patient quality-of-life (QOL).  Treatment of rhinophyma is challenging as topical and systemic pharmacotherapies have shown limited effectiveness.  These investigators presented a case of a 39-year old African-American male with longstanding, mild rhinophyma, who was successfully treated with 2 sessions of fractionated CO2 laser.  They also reviewed the medical literature on fractionated CO2 laser treatment of rhinophyma.  To the best of their knowledge, this was the first report of successful treatment of rhinophyma using fractionated CO2 laser in an African-American man.  The authors believed that fractionated CO2 laser may be a safe and effective treatment modality for rhinophyma in skin of color patients (Fitzpatrick IV to VI) and early intervention with fractionated CO2 laser to prevent rhinophyma worsening may yield better results than late intervention.  These preliminary findings need to be validated by well-designed studies.

Ablative Laser Treatment (Non-Contact, Full-Field and Fractional Ablation) for Wound Healing

Shumaker and co-workers (2012) stated that skin compromised by traumatic scars and contractures can manifest decreased resistance to shearing and other forces, while increased tension and skin fragility contribute to chronic erosions and ulcerations.  Chronic wounds possess inflammatory mediator profiles and other characteristics, such as the presence of biofilms, that can inhibit healing.  These investigators reported the findings of 3 patients with multiple traumatic scars related to blast injuries who received a course of ablative fractional laser resurfacing (AFR) for potential mitigation of contractures, poor pliability, and textural irregularity.  Patients also had chronic focal erosions or ulcerations despite professional wound care.  All patients experienced incidental rapid healing of their chronic wounds within 2 weeks of their initial ablative fractional laser treatment.  Healing was sustained throughout the treatment course and beyond and was associated with gradual enhancements in scar pliability, texture, durability, and range of motion.  The authors concluded that the unique pattern of injury associated with ablative fractional laser treatment may have various potential wound-healing advantages.  These advantages included the novel concept of photo-microdebridement, including biofilm disruption and the stimulation of de-novo growth factor secretion and collagen re-modeling.  The authors concluded that If confirmed, traditional wound and scar treatment paradigms could shift toward earlier intervention with anticipated benefits in rehabilitation and a more favorable trajectory for wound healing.  Moreover, they stated that prospective studies are needed to clarify any potential role for AFR as an adjunct to traditional wound management and in applications for the management of traumatic scars in general. 

Basnett and associates (2015) noted that Leishmaniasis is a vector borne disease; its manifestations range from localized skin ulceration to lethal visceral disease.  With increased global travel, cutaneous leishmaniasis (CL) is becoming more common in developed nations.  However, current therapeutic options are limited.  These investigators reported on the case of a 16-year old girl who presented with several non-tender, non-healing CL wounds on her bilateral upper and lower extremities; AFR was used in conjunction with topical paromomycin via laser-assisted delivery to treat the largest non-healing CL wound on the patient's distal lower extremity.  Upon follow-up after 2 treatments with AFR, the patient's wound healed completely without evidence of infection and with minimal scarring.  The authors concluded that AFR with laser-assisted delivery of topical paromomycin represents a novel therapeutic option for resistant, non-healing CL wounds.  The technique may prove additionally useful for concurrent mitigation of scarring related to CL.  These preliminary findings need to be validated by well-designed studies.

Phillips and colleagues (2015) stated that treating post-traumatic lower extremity wounds can be challenging, especially in elderly patients.  Recently, the use of fractional carbon dioxide (CO2) laser has been shown to improve wound healing in scar-related wounds.  These researchers used this treatment modality in post-traumatic wounds that were slow to heal in 3 elderly patients.  Each wound underwent 1 fractional CO2 laser treatment.  The wound base was treated at 30 mJ and 5 % density.  The entire wound edge and 1 to 2 cm into the normal surrounding skin were treated at 50 mJ and 5 % density.  One pass was completed at 150 Hz per treatment.  Treatments were well-tolerated with only mild discomfort.  Each wound healed by 60 % or greater within 3 weeks.  No AEs were reported aside from mild and transient erythema at site of treatment.  The authors concluded that fractional CO2 laser treatment appeared to accelerate healing in each of these post-traumatic wounds; it may be a helpful adjunct in non-healing post-traumatic wounds.  Moreover, they stated that controlled studies are needed to further validate this modality as a 2nd-line treatment for difficult-to-heal lower-extremity wounds.

Krakowski and co-workers (2016) stated that AFR is an emerging therapy for chronic wounds.  In a case-series study, these researchers reported the successful use of AFR to facilitate the healing of chronic wounds in 2 pediatric patients.  These patients had chronic wounds within scars that were treated with a micro-fractionated CO2 laser in a single pass at a pulse energy of 50 mJ and a treatment density of 5 %; 1 patient had 1 treatment and the other had 2 treatments 1 month apart.  Ablative fractional laser resurfacing led to rapid healing of chronic wounds in both patients.  The wounds remained epithelialized after 9 months in 1 patient and 4 months in the other.  There were no complications.  The authors concluded that the combination of tolerability and efficacy observed in these cases introduced AFR as a potential promising adjunct to existing treatments for chronic, non-healing wounds in the pediatric population.

In a systematic review, Suter and colleagues (2017) examined a potential benefit of laser use in the treatment of recurrent aphthous stomatitis (RAS).  The primary outcome variables were pain relief, duration of wound healing and reduction in episode frequency.  A PICO approach was used as a search strategy in Medline, Embase and Cochrane databases.  After scanning and excluding titles, abstracts and full texts, a total of 11 studies (10 RCTs and 1 non-RCT) were included.  Study selection and data extraction were carried out by 2 observers.  Laser treatment included Nd:YAG laser ablation, CO2 laser applied through a transparent gel (non-ablative) and diode laser in a low-level laser treatment (LLLT) mode.  Control groups had placebo, no therapy or topical corticosteroid treatment.  Significant pain relief immediately after treatment was found in 5 out of 6 studies.  Pain relief in the days following treatment was recorded in 7 studies.  The duration of RAS wound healing was also reduced in 5 studies.  However, criteria of evaluation differed between the studies.  The episode frequency was not evaluated as only 1 study addressed this outcome parameter, but did not discriminate between the study (LLLT) and control (corticosteroid) groups.  Jadad scores (ranging from 0 to 5) for quality assessment of the included studies ranged between 0 and 2 (mean = 1.0) for studies analyzing pain relief and between 0 and 3 (mean = 1.1) for studies evaluating wound healing.  The use of lasers (CO2 laser, Nd:YAG laser and diode laser) to relieve symptoms and promote healing of RAS was a therapeutic option.  The authors concluded that more studies for laser applications are needed to demonstrate superiority over topical pharmaceutical treatment and to recommend a specific laser type, wavelength, power output and applied energy (ablative versus photo-biomodulation).

Laser for the Treatment of Diabetic Skin Wounds

In a systematic review, Kwan and colleagues (2019) evaluated published cell studies and animal experimental reports on the efficacy of selected biophysical energies (BPEs) in the treatment of diabetic foot ulcers.  These BPEs included electrical stimulation (ES), pulsed electro-magnetic field (PEMF), extra-corporeal shock-wave (ECSW), photo energies and ultra-sound (US).  Databases searched included CINAHL, Medline and PubMed from 1966 to 2018.  Reviewed studies included animal and cell studies on treatment with BPEs compared with sham, control or other BPEs.  Information regarding the objective measures of tissue healing and data was extracted.  A total of 82 studies were eventually selected for the critical appraisal: 5 on PEMF, 4 each on ES and ECSW, 66 for photo energies, and 3 about US.  Based on the percentage of original wound size affected by the BPEs, both PEMF and low-level laser therapy (LLL) demonstrated a significant clinical benefit compared to the control or sham treatment, whereas the effect of US did not reveal a significance.  The authors concluded that these findings indicated potential benefits of selected BPEs in the management of diabetic skin wounds.  However, due to the heterogeneity of the current clinical trials, comprehensive studies using well-designed trials are needed to confirm these findings.

Actinic Cheilitis

Salgueiro and colleagues (2019) noted that actinic cheilitis (AC) is a potentially malignant disorder caused by excessive sun exposure.  It affects the lower lip of individuals, mostly those with light skin color.  Different treatments have been proposed for AC; however, no consensus has been reached on the best option available.  These researchers described the results of a computer-based systematic search conducted on electronic data-bases to identify the best therapies.  A total of 29 journal articles were selected, and the results were divided according to the type of treatment employed: laser therapy, chemotherapy agents, surgical treatment, and application of anti-inflammatory agents.  Clinically, PDT showed positive results, with improvement in up to 100 % of the patients; however, histopathological improvement varied greatly, from 16 % to 100 %.  Among the chemotherapeutic agents assessed, imiquimod showed the best results: clinical improvement in 80 % to 100 % of the patients, and histopathological improvement in 73 % to 100 %.  Regarding studies describing surgical approaches, the main focus was the search for the best technique, rather than the cure of AC.  Finally, studies employing anti-inflammatory agents were sparse and had small samples, therefore providing limited findings.  The authors concluded that the available scientific evidence on the treatment of AC is scarce and heterogeneous, PDT, and imiquimod application are promising.

Lai and associates (2020) stated that no large studies have defined the best treatment of AC.  These researchers carried out a systematic review to define the best therapies for AC in clinical response and recurrences.  They identified 444 papers, and 49 were finally considered, including 789 patients and 843 treated areas.  The following therapies were recorded in order of frequency: laser therapy, PDT, 3 % diclofenac in 2.5 % hyaluronic acid, PDT + 5 % imiquimod, aminolevulinic acid-laser or methyl-aminolevulinic acid-laser, 5 % imiquimod, fluorouracil, partial surgery, 0.015 % ingenol mebutate, 50 % trichloroacetic acid, and laser + PDT.  Concerning the primary outcome, complete clinical response was achieved in 76.5 % of patients, and 10.2 % had clinical recurrences.  Partial surgery and laser therapy showed the highest complete response rates (14 of 14 [100 %] and 244 of 260 [93.8 %], respectively) with low recurrences.  Only a limited number of patients were treated with other therapies, with the exception of PDT, with 68.9 % complete responses and 12.6 % of recurrences.  Interestingly, when combined with 5 % imiquimod, the efficacy of PDT was significantly enhanced.  The authors concluded that laser therapy appeared the best option among non-surgical approaches for AC, and PDT showed higher efficacy when sequentially combined with 5 % imiquimod.  These researchers stated that larger studies are needed to confirm these data.  The major drawback of this study was heterogeneity across studies.

Furthermore, an UpToDate review on “Actinic cheilitis” (Mowad, 2020) states that “For patients with multifocal or diffuse mild to moderate actinic cheilitis, we suggest field therapy with topical fluorouracil or imiquimod rather than photodynamic therapy or laser therapy”.

Hidrocystoma

Trischman and Scott (2020) stated that although various therapeutic options for hidrocystomas have been described, the comparative efficacy of these therapies is poorly understood.  These researchers carried out a systematic review of the literature describing the treatment of hidrocystomas.  Treatment modalities were categorized as destructive surgical procedures, skin-directed therapies, systemic medical therapies, general measures, or combined.  Patient and tumor characteristics, response rate, recurrence rate, and adverse effects were extracted from each article.  A total of 94 articles involving 192 patients and 255 unique treatment events were included in the final analysis.  Destructive surgical procedures had an overall response rate (ORR) and recurrence rate of 92.9 % and 10.8 %, respectively.  Skin-directed therapies had an ORR of 72.6 %.  The ORR to systemic medical therapies was 71.4 %.  Solitary hidrocystomas were primarily treated with destructive surgical procedures, including excision, which was associated with a 4.7 % recurrence rate.  Multiple hidrocystomas were successfully treated with a variety of therapies, including destructive surgical procedures and skin-directed therapies requiring ongoing or repeated therapy.  The authors concluded that excision has the highest efficacy for solitary hidrocystomas.  A number of therapies have shown efficacy for multiple hidrocystomas, including lasers, intra-cystic trichloroacetic acid, intra-cystic hypertonic glucose, topical and oral anticholinergics, and botulinum toxin (BTX).  Aluminum chloride is associated with a low response rate.  These researchers stated that larger comparative studies are needed to further examine the optimal treatments for solitary and multiple hidrocystomas.

Furthermore, an UpToDate review on “Nevus sebaceus and nevus sebaceus syndrome” (Wright, 2020) states that “The definitive treatment of nevus sebaceus is full-thickness excision.  However, the necessity and timing of excision to prevent possible future malignancy are still debated.   The decision to excise the lesion should be made in individual patients, based upon age, extension and location of the lesion, and the patient's or parents' concern about the cosmetic appearance and/or risk of malignancy.  Since the risk of malignant transformation appears to be lower than previously believed, observation may be reasonable for lesions that do not cause cosmetic concern.  Alternatives to surgical excision include photodynamic therapy, carbon dioxide laser resurfacing, and dermabrasion.  However, since these treatment modalities do not completely remove the lesion, the risk of recurrence and potential for neoplasm development remains”.

Laser Removal for Recurrent Pilonidal Cyst

Pronk and colleagues (2018) stated that it has been suggested that removal of body hair in the sacrococcygeal area prevents recurrence after surgery for sacrococcygeal pilonidal sinus disease (SPSD).  In a systematic review, these researchers examined the literature regarding the effect of hair depilation on the recurrence rate in patients surgically treated for SPSD.  They carried out a systematic search in PubMed, Embase, and the Cochrane Library by using synonyms for SPSD.  Title, abstract, and full text were screened by 2 independent reviewers.  Data were systematically collected from all included studies by using a standardized data extraction form.  The search and selection yielded 14 studies, involving 963 patients.  The study design of the included studies included retrospective cohort (n = 7), prospective cohort (n = 3), RCT (n = 2), and case-control (n = 2).  The mean length of follow-up was 37.0 (standard error [SE] of the mean: 35.0) months.  The recurrence rate was 9.3 % (34 out of 366 patients) in patients who had laser hair removal, 23.4 % (36 out of 154 patients) in those who had razor shaving/cream depilation, and 19.7 % (85 out of 431 patients) in those who had no hair removal after surgery for SPSD.  The authors concluded that the findings of this systematic review showed a lower recurrence rate after laser hair removal compared to no hair removal and razor/cream depilation.

The American Society of Colon and Rectal Surgeons' clinical practice guidelines on “The management of pilonidal disease” (Johnson et al, 2019) stated that “Elimination of hair from the gluteal cleft and surrounding skin, by shaving or laser epilation, may be used for both acute and chronic pilonidal disease in the absence of abscess as a primary or adjunct treatment measure”.

Liyanage et al (2020) noted that pilonidal disease is a chronic condition involving the sacrococcygeal area.  It can have a significant impact on quality of life (QOL), social activities and occupation.  Surgery is the mainstay of treatment; however, laser depilation has been proposed as an adjunct to surgery and has shown improved results in some studies.  These investigators presented their experience of laser depilation in the treatment of pilonidal disease in a district general hospital setting in the United Kingdom.  They prospectively analyzed data of all consecutive patients who received laser depilation after elective surgery for pilonidal disease.  Subjects were offered a minimum of 2 sessions of laser depilation.  The primary outcome measure was disease recurrence.  Evidence of new symptoms or signs of pilonidal disease after 1 year from the latest surgical intervention was defined as recurrent disease.  Data were presented as medians with interquartile ranges (IQRs).  A total of 64 patients underwent laser depilation after elective surgery between June 1, 2013 and June 1, 2018; 57 were eligible for final analysis; 65 % of patients received 6 or more sessions of laser treatment.  There were no short- or long-term complications related to laser depilation.  Patients who had more than 2 sessions of laser depilation showed an improved recurrence rate.  Overall, recurrence rate in this series was 12 % at a median follow-up of 172 weeks.  The authors concluded that laser depilation was a safe and effective adjunct to surgery in minimizing the recurrence of pilonidal disease.  Patients with primary pilonidal disease and those who were undergoing minimally invasive surgery may also benefit from adjuvant laser depilation.  Moreover, these researchers stated that further high-quality control trials are needed to examine its safety and efficacy.

Yardimci (2020) noted that an ideal treatment for pilonidal disease should feature a low recurrence rate, minimal incision, and rapid return to daily activities.  These researchers compared the outcomes of the well-defined Karydakis technique (KT) and a combination of pit excision (PE) and sinus tract ablation using 1,470-nm diode laser.  From January 2016 to January 2018, patients diagnosed with uncomplicated early-stage pilonidal sinus disease were enrolled and treated randomly, using KT (n = 28) or a PE/laser ablation technique (PE + LAT; n = 30).  The mean operative times were 36.4 (25 to 45) mins in the KT group and 15.1 (12 to 20) mins in the PE + LAT group.  Post-operative visual analog scale (VAS)  pain scores were 4.4 in the KT group and 2.1 in the PE + LAT group.  The time periods to return to normal daily activities were 2.6 (1 to 5) days in the PE + LAT group and 12.8 (10 to 20) days in the KT group.  The mean Likert satisfaction scores were 3.8 in the KT group and 4.8 in the PE + LAT group.  The groups did not differ in terms of recurrence.  The authors concluded that compared with the KT, the PE + LAT was associated with a shorter operative time, a more rapid return to normal activities, less pain, and a higher level of subjective satisfaction.  These investigators found that the PE + LAT was better than the KT for patients with early-stage disease.

Harju et al (2021) stated that pilonidal disease is common, and it afflicts especially young adults, causing disability.  Several types of treatment methods are applicable, but no consensus exists regarding the best method.  In a retrospective study, these researchers examined the novel radial laser probe treatment in pilonidal disease and reported the success rate and recurrence rate.  They studied 86 patients who, according to the authors’ hospital patient records, underwent radial laser probe surgery between January 2017 and September 2019.  At a mean follow-up time of 14 months, the success rate at 2 months was 86 %.  Most operations were carried out under local anesthesia on a day-surgery basis.  The recovery time was rapid, and median sick leave was 12 days.  Of those initially successfully treated, 3 % developed a recurrence.  Altogether 17 % of the patients underwent a re-operation.  Spillage of pus during surgery, however, reduced the success rate to 53 %.  The authors concluded that the radial laser probe operation appeared to be a suitable method to cure pilonidal disease, with good recovery rates and only a few recurrences.  This operation could be performed under local anesthesia, in most cases on a day-surgery basis, and the recovery time was short.  Complicated cases with acute pus spillage appeared, however, unsuitable for this kind of surgery.  Moreover ,these researchers stated that to determine which minimally invasive method is the best for pilonidal disease would require prospective, randomized studies.  The authors stated that this study had 2 major drawbacks, namely the small number of patients as well the retrospective nature of this study; however, these findings showed that the healing rate was 53 % among patients when spillage of pus occurred during surgery, whereas the healing rate was 93 % when there was no spillage of pus during surgery.  This indicated that a radial laser probe procedure was most appropriate for simple pilonidal sinuses.  Furthermore, this finding was useful when planning prospective, randomized studies to evaluate this new method more thoroughly.

Furthermore, an UpToDate review on “Pilonidal disease” (Johnson, 2021) states that “Following healing of a drained pilonidal abscess, patients should begin regular gluteal cleft shaving or another method of epilation (e.g., laser, depilatory cream [e.g., Nair]), as gluteal cleft hair has been implicated in the pathogenesis of pilonidal disease.  By contrast, there is evidence that razor hair-shaving may increase the risk of recurrence following definitive surgery for pilonidal disease, and it is not known whether gluteal cleft hair removal is beneficial to completely asymptomatic patients”.

Laser Hair Removal for the Treatment of Acne Keloidalis Nuchae

Maranda and colleagues (2016) stated that acne keloidalis nuchae (AKN) is a chronic inflammatory condition that leads to fibrotic plaques, papules and alopecia on the occiput and/or nape of the neck.  Conventional medical management focuses on prevention, use of oral and topical antibiotics, and intralesional steroids in order to decrease inflammation and secondary infections.  Unfortunately, therapy may require months of treatment to achieve incomplete results and recurrences are common.  Surgical approach to treatment of lesions is invasive, may require general anesthesia and requires more time to recover.  Light and laser therapies offer an alternative treatment for AKN.  These investigators reviewed the currently available literature on the treatment of AKN.  While all modalities were discussed, light and laser therapy were emphasized due to its relatively unknown role in clinical management of AKN.  The most studied modalities in the literature were the 1,064-nm neodymium-doped yttrium aluminum garnet(Nd:YAG) laser, 810-nm diode laser, and CO2 laser, which allow for 82 to 95 % improvement in 1 to 5 sessions.  Moreover, side effects were minimal with transient erythema and mild burning being the most common.  The authors concluded that further randomized, larger-scale, head-to-head control trials are needed to determine optimal treatments.

Tawfik et al (2017) examined the safety and effectiveness of Alexandrite laser in the treatment of different lesions of AKN.  A total of 17 male patients with AKN received 6 sessions of 755-nm Alexandrite laser.  Papule and pustule count, keloidal plaque size, pliability, tenderness, and itching were assessed at the 4th session and 4 weeks after the 6th session.  Patient satisfaction and Dermatology Life Quality Index (DLQI) questionnaire were performed at the end of treatment.  Patients were followed-up for 3 months after the final treatment.  There was a significant decrease in the mean papule, pustule count, keloidal plaque size, and pliability at the 4th and 6th laser sessions when compared with baseline.  Reduction of the hair density in the treated area was the only complication observed, which was accepted by the patients because of its reversible course.  There was a statistically significantly higher percentage of improvement in the early lesions (papulopustular) compared with late (keloidal plaque) lesions.  By the end of laser sessions, DLQI scores were significantly reduced.  Temporary hair loss was noted in 4 patients in the treated sites; and no lesional recurrence was detected in the follow-up period.  The authors concluded that using 755-nm Alexandrite laser for treatment of AKN was a safe and effective procedure with low recurrence rates.  Alexandrite laser can significantly improve the QOL of those patients suffering from this disfiguring chronic disorder.

In a randomized, single-blinded, within-patient right-left controlled trial (n = 13), Woo and associates (2018) examined the effectiveness of the long-pulsed 1,064-nm Nd:YAG laser and topical steroids as a treatment for AKN compared to topical steroids alone.  A total of 8 monthly laser treatments were carried out on the treated half of the scalp, and triamcinolone 0.1 % cream was applied to both sides twice-daily.  Treatment response was measured using a global assessment score (0 to 10).  The laser-treated side showed greater improvement in global assessment score.  The mean change was -3.2 (-49.2 %) on the treated side and -2.2 (-32.8 %) on the control side (p = 0.144).  Papules responded well to laser treatment, while larger plaques and nodules showed limited improvement.  In the 10 patients with papules only, the difference in improvement between the treated and control sides was statistically significant (mean change was -3.5 [-59.3 %] for the treated side and -1.8 [-29.5 %] for the control side, p = 0.031).  The authors concluded that the long-pulsed Nd:YAG laser in conjunction with topical steroids showed promising results in the treatment of AKN, especially the papular component, and was well-tolerated by patients.

In a comparative study, Gamil and co-workers (2018) examined the efficacy of Er:YAG laser in the treatment of AKN as compared to long pulsed Nd:YAG laser.  This study was carried out on 30 male patients with AKN; ages ranged from 19 to 47 years with a mean age of 36.87 ± 7.8 years.  Patients were divided randomly into 2 groups of 15 patients, each receiving 6 sessions of either Er:YAG or long-pulsed Nd:YAG laser therapy.  A statistically significant decrease in the number of papules was detected at the end of therapy in both groups, with a mean of 91.8 % improvement in the Er:YAG group versus 88 % in the Nd:YAG group.  A significant decrease in plaques count was detected only in the Er: YAG group while a significant decrease in plaques size and consistency was recorded in both groups.  The authors concluded that Er: YAG laser proved to be a potentially effective and safe modality both in the early and late AKN lesions.

Roberts et al (2019) noted that individuals with skin of color are a rapidly growing portion of the cosmetic procedures market.  There are unique challenges to treating skin conditions in skin of color patients.  This article and roundtable discussion focused on the use of energy-based modalities, especially a 650-microsecond 1,064nm laser that delivers energy in a collimated beam.  Alone or in combination with other therapies, the 650-microsecond 1,064nm laser has been used successfully to treat melasma, acne, post-inflammatory hyper-pigmentation, pseudo-folliculitis barbae, hair removal, AKN, and aging skin in skin of color.

Umar (2019) stated that currently, the only treatments with curative possibility for AKN are surgical and laser hair removal.  In general, long-pulse, long-wave lasers are favored, including the long-pulsed Alexandrite 755 nm, the long-pulsed Diode 800 nm, and the long-pulsed Nd-YAG 1,064 nm.   These lasers can penetrate deeply enough to target the entire dermal expanse of the average follicular length of 2 to 4 mm because of their longer wavelengths.  Of these lasers, Nd-YAG is favored by the author because it penetrates the deepest of the 3 lasers (5 to 7 mm) and is the least absorbed by melanin, resulting in lesser skin damage for the most affected demographic (men of color).  The safety profile is additionally enhanced by contact or the dynamic cooling of the epidermis.

Furthermore, an UpToDate review on “Acne keloidalis nuchae” (Mackay-Wiggan and Husain, 2021) states that “Surgical therapies are indicated for the treatment of extensive scarring seen in plaque or tumor stage AKN.  Once large plaques have developed, surgical options are the only effective recourse.  Surgery can also be used to remove the site of disease in patients with active disease that is poorly responsive to medical therapy.  AKN has been successfully treated with scalpel excision, electrosurgical excision, and laser excision”.

Morphea (Localized Scleroderma)

Szczepanik-Kułak et al (2021) noted that morphea, also known as localized scleroderma, comprises a set of autoimmune sclerotic skin diseases.  It is characterized by inflammation and limited thickening and induration of the skin; however, in some cases, deeper tissues might also be involved.  Although morphea is not considered a life-threatening disease, the apparent cosmetic disfigurement, functional or psychosocial impairment affects multiple fields of patients' QOL.  Treatment for morphea is often unsatisfactory with many therapies that have only limited effectiveness or considerable side effects.  Due to the advances in the application of lasers and their possible beneficial effects, these researchers examined the reported usage of laser in morphea.  They carried out a systematic review of available literature, performed with Medline, Cinahl, Central, Scopus, Web of Science, and Google Scholar databases.  These investigators identified a total of 20 relevant studies (Medline, n = 10; Cinahl, n = 1; Central, n = 0; Scopus, n = 2; Web of Science, n = 5; Google Scholar, n = 2) using laser therapy for morphea.  A total of 8 studies were focused on the use of PDL, 6 on fractional lasers (CO2 and Er:YAG), 4 on excimer, and 2 on either alexandrite or Nd:YAG.  Moreover, these researchers stated the findings of this systematic review should encourage the pursuit of controlled studies with a greater number of patients to better determine the role of laser in the treatment of morphea.

Cutaneous Amyloidosis

Ahramiyanpour et al (2022) stated that with the investigation of the effectiveness of laser therapy in primary localized amyloidosis (PLCA) only recently starting to materialize, these investigators reviewed the currently available evidence on laser therapy in the management of the disease.  They searched PubMed, Scopus, Embase, Web of Science, Cochrane, and ProQuest online databases with a specified search strategy, evaluated the quality of each study, and then extracted the eligible data.  A total of 18 studies (5 RCTs, 1 non-RCT, 3 case-series studies, and 9 case reports) were included.  Overall, CO2, Nd:YAG, PDL, Er:YAG, and yttrium/erbium fiber were the studied lasers.  A total of 155 cases underwent laser therapy, with CO2 being the most frequent laser.  Almost all studies demonstrated significantly desirable outcomes, while only mild and transient side effects were noted.  The authors concluded that even though the studies' results were significant, they noticed that implementing a consistent methodology and a standardized objective assessment method was missing.  Thus, these investigators recommend that future studies be carried out with less heterogeneous data for a more definite conclusion.

Dissecting Cellulitis

Thomas and Aguh (2021) noted that dissecting cellulitis is a chronic inflammatory dermatosis that results in disfiguring and painful, purulent lesions.  Treatment of patients with disease resistant to standard therapies, including intralesional or topical steroids or antibiotics, can be a dilemma for clinicians.  These investigators carried out a systematic review of the literature in November 2018 to locate studies that presented therapeutic options and outcomes of patients who failed prior treatment with standard therapies.  They identified 57 articles of interest, with 53 being case studies or series.  Isotretinoin was the most often reported, but the response was limited.  Biologics and laser therapy were used less often but showed a better chance of remission.  X-ray epilation and surgical excision demonstrated the best remission rates but can be complicated by serious morbidity.  The authors proposed a regimen for the treatment of recalcitrant cases of dissecting cellulitis.  Moreover, these researchers stated that in the future, more robust studies including RCTs are needed to identify the preferred therapeutic options for refractory dissecting cellulitis.

Penile Intraepithelial Neoplasia

Issa et al (2022) stated that penile intraepithelial neoplasia (PeIN) is a rare skin condition with potential to progress to invasive penile cancer.  These investigators carried out a systematic review of therapeutic options and outcomes for PeIN.  Topical agents showed response and recurrence rates of 40 % to 100 % and 20 % for imiquimod, and 48 % to 74 % and 11 % for 5-fluorouracil, respectively.  Discontinuation of topical agents because of side effects was observed in 12 % of cases.  Response rates for laser therapies were 52 % to 100 %, with recurrence in 7 % to 48 % of cases and a change in penile sensitivity in 50 %.  Circumcision cleared preputial PeIN.  Rates of recurrence following surgical treatment of glans PeIN were 25 % for wide local excision, 4 % for Mohs surgery, 5 % for total glans resurfacing, and 10 % for glansectomy.  There were limited data on factors predictive of treatment response and on sequencing of therapeutic options.  The authors concluded that several therapeutic options are available for men with precancerous lesions of the foreskin or glans; and close follow-up is needed as lesions could recur or progress to invasive penile cancer.

Pang et al (2022) noted that penile cancer (PeCa) is a rare disease with a global incidence of 36,068 new cases in 2020; accounting for 0.4 % of all male malignancies.  The surgical management of PeCa depends on the location of the tumor and depth of invasion.  These investigators reviewed the oncological and functional outcomes of penile-preserving surgery (PPS).  They carried out a PubMed search until July 2021 on PPS for PeCa; a narrative review on different penile-sparing approaches and outcomes was conducted.  These researchers stated that PPS is now the standard of care (SOC) in specialist centers for distal tumors not involving the corpus cavernosa.  Laser therapy, glans re-surfacing, and wide local excision (WLE) are options for superficial lesions, while glansectomy is needed for lesions invading into the corpus spongiosum.  The authors concluded that PPS aimed to preserve urinary and sexual function without compromising oncological outcomes.

Vulvar Inflammatory Skin Conditions

In a systematic review, Kim et al (2023) noted that conventional treatments for vulvar inflammatory and malignant conditions include surgical excision, PDT, and laser ablation.  These investigators highlighted the use of laser therapies for vulvar conditions, with the most evidence for CO2 laser for lichen sclerosus and vulval intraepithelial neoplasia.  The heterogeneity of the studies precluded these researchers from providing a SOC in laser type and laser settings.  While most studies reported minimal short-term complications, there is a paucity of data on long-term outcomes.  The majority of the studies did not specify Fitzpatrick skin type of patients, limiting the ability to comment on the safety of laser-based devices across a broader range of skin types.  The authors concluded that more robust studies are needed to establish guidelines for optimal recommendations for use of lasers in vulvar inflammatory and neoplastic skin conditions.

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References