Double Balloon Enteroscopy

Number: 0737

Table Of Contents

Policy
Applicable CPT / HCPCS / ICD-10 Codes
Background
References

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Policy

Scope of Policy

This Clinical Policy Bulletin addresses double balloon enteroscopy.

1. Medical Necessity

   Aetna considers double balloon enteroscopy (DBE) medically necessary for the following indications:

   1. For dilation of small bowel strictures in Crohn’s disease; or
   2. For evaluating suspected small bowel malignancies (e.g., adenocarcinoma, lymphoma, gastro-intestinal (GI) stromal tumors, metastatic tumors); or
   3. For evaluating the colon in the case of incomplete colonoscopy; or
   4. For individuals with suspected Meckel’s diverticulum (e.g., GI bleeding or abdominal pain) and indefinite diagnostic imaging work-up (e.g., computed tomography (CT), or Meckel’s scan); or
   5. For investigating suspected small intestinal bleeding in persons with objective evidence of recurrent, obscure GI bleeding (e.g., iron-deficiency anemia, positive fecal occult blood test, or visible bleeding) who have had upper and lower GI endoscopies (esophagogastroduodenoscopy (EGD) and colonoscopy) that have failed to identify a bleeding source; or
   6. For initial diagnosis in persons with suspected Crohn's disease (abdominal pain, diarrhea, elevated erythrocyte sedimentation rate, elevated white blood cell count, fever, GI bleeding, or weight loss) without evidence of disease on conventional diagnostic tests, including small-bowel follow-through and upper and lower endoscopy (EGD and colonoscopy); or
   7. For removing entrapped foreign bodies in the small bowel (e.g., retained video capsule); or
   8. For removing large polyps (greater than 10 mm) of the small bowel in persons with Peutz-Jeghers syndrome; or
   9. For treating members with GI bleeding when the small intestine has been identified as the source of bleeding; or
   10. For use in conjunction with endoscopic retrograde cholangio-pancreatography (ERCP) in individuals with surgically altered upper GI anatomy.

2. Experimental and Investigational

   Aetna considers DBE experimental and investigational for all other indications including the following (not an all-inclusive list) because its effectiveness for indications other than the ones listed above has not been established:

   1. Detection of neuroendocrine tumors of the small bowel;
   2. Diagnosis of pelvic mass penetrating intestine, including gossypiboma;
   3. Diagnosis of pyogenic granuloma;
   4. Treatment of intussusception;
   5. Treatment of post-operative bile leakage in persons who had undergone hepatico-jejunostomy.

3. Related Policies

   • CPB 0588 - Capsule Endoscopy

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Table:

CPT Codes / HCPCS Codes / ICD-10 Codes

Code	Code Description
There is no specific code for double balloon enteroscopy:
Other CPT codes related to the CPB:
43260 - 43273	Endoscopic retrograde cholangiopancreatography (ERCP)
45378	Colonoscopy, flexible; diagnostic, including collection of specimen(s) by brushing or washing, when performed (separate procedure)
47780	Anastomosis, Roux-en-Y, of extrahepatic biliary ducts and gastrointestinal tract
47785	Anastomosis, Roux-en-Y, of intrahepatic biliary ducts and gastrointestinal tract
74176	Computed tomography, abdomen and pelvis; without contrast material
74177	Computed tomography, abdomen and pelvis; with contrast material(s)
74178	Computed tomography, abdomen and pelvis; without contrast material in one or both body regions, followed by contrast material(s) and further sections in one or both body regions
78290	Intestine imaging (eg, ectopic gastric mucosa, Meckel's localization, volvulus)
Other HCPCS codes related to the CPB:
C7541	Diagnostic endoscopic retrograde cholangiopancreatography (ercp), including collection of specimen(s) by brushing or washing, when performed, with endoscopic cannulation of papilla with direct visualization of pancreatic/common bile ducts(s)
C7542	Endoscopic retrograde cholangiopancreatography (ercp) with biopsy, single or multiple, with endoscopic cannulation of papilla with direct visualization of pancreatic/common bile ducts(s)
C7543	Endoscopic retrograde cholangiopancreatography (ercp) with sphincterotomy/papillotomy, with endoscopic cannulation of papilla with direct visualization of pancreatic/common bile ducts(s)
C7544	Endoscopic retrograde cholangiopancreatography (ercp) with removal of calculi/debris from biliary/pancreatic duct(s), with endoscopic cannulation of papilla with direct visualization of pancreatic/common bile ducts(s)
C7560	Endoscopic retrograde cholangiopancreatography (ercp) with removal of foreign body(s) or stent(s) from biliary/pancreatic duct(s) and endoscopic cannulation of papilla with direct visualization of pancreatic/common bile duct(s)
ICD-10 codes covered if selection criteria are met :
D50.0 - D50.9	Iron deficiency anemia
D62	Acute posthemorrhagic anemia
D72.820 - D72.829	Elevated white blood cell count
K50.00 - K50.919	Crohn's disease [small bowel strictures]
K52.21 - K52.9	Allergic and dietetic gastroenteritis and colitis and other specified noninfective gastroenteritis and colitis
K63.5	Polyp of colon
K92.0 - K92.2	Hematemesis, melena and unspecified gastrointestinal hemorrhage
Q43.0	Meckel's diverticulum (displaced) (hypertrophic)
Q85.81, Q85.82, Q85.83, Q85.89	Other phakomatoses, not elsewhere classified
R10.0 - R10.13 R10.30 - R10.33 R10.84	Abdominal pain
R19.4 - R19.5	Change in bowel habit and other fecal abnormalities
R19.7 - R19.8	Diarrhea and other specified symptoms and signs involving the digestive system and abdomen
R50.2 - R50.9	Fever of other and unknown origin
R63.4	Abnormal weight loss
R63.6	Underweight
R70.0	Elevated erythrocyte sedimentation rate
R71.0 - R71.8	Abnormality of red blood cells
T18.3xx+	Foreign body in small intestine
ICD-10 codes not covered for indications listed in the CPB (not all-inclusive):
C7A.010 - C7A.019	Malignant carcinoid tumors of the small intestine
C17.0 - C17.9	Malignant neoplasm of small intestine
C76.3	Malignant neoplasm of pelvis [pelvic mass]
C78.4	Secondary malignant neoplasm of small intestine
C81.00 - C88.9	Hodgkin’s lymphoma, follicular lymphoma, non-follicular lymphoma, mature T/NK-cell lymphomas, other specified and unspecified types of non-Hodgkin lymphoma, other specified types of T/NK-cell lymphoma, and malignant immunoproliferative disease and certain other B-cell lymphomas
D3A.010 - D3A.019	Benign carcinoid tumors of the small intestine
K56.1	Intussusception
K91.89	Other postprocedural complications and disorders of digestive system [post-operative bile leakage]
L98.0	Pyogenic granuloma
R19.00	Intra-abdominal and pelvic swelling, mass and lump, unspecified site
R19.07	Generalized intra-abdominal and pelvic swelling, mass and lump
R19.09	Other intra-abdominal and pelvic swelling, mass and lump
T81.509A -T81.509S	Unspecified complication of foreign body accidentally left in body following unspecified procedure [gossypiboma]
T81.599A - T81.599S	Other complications of foreign body accidentally left in body following unspecified procedure [gossypiboma]

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Background

Preliminary findings suggested that DBE is useful in the management of patients with small bowel lesions, especially for individuals with obscure gastro-intestinal bleeding (OGIB).  The complication rate of DBE is low; severe complications such as pancreatitis and perforation have been reported in approximately 1 % of all diagnostic DBEs.  Moreover, the complication rate of therapeutic DBEs is higher than diagnostic DBEs, but is comparable with the conventional endoscopy (May and Ell, 2006).

Sunada and associates (2005) evaluated the clinical outcome of DBE focusing on the involvement of neoplasms in strictures of the small intestine.  By means of DBE, strictures of the small intestine were found in 17 out of 62 patients.  These 17 consecutive patients were subjected to analysis – DBE contributed to the diagnosis of small intestinal neoplasms in 3/17 patients by direct observation of the strictures as well as by biopsy sampling.  Surgical procedures were chosen for these 3 patients, while balloon dilation was chosen for the strictures in 4 patients diagnosed with inflammation without neoplasm.  The authors concluded that DBE is a useful method for the diagnosis and treatment of strictures in the small bowel.

In a retrospective analysis, Di Caro and colleagues (2005) assessed the indications, safety, as well as clinical impact of DBE.  A total of 62 patients with suspected or documented small bowel diseases were investigated by DBE.  A total of 89 procedures were performed (26 and 9 patients from the oral or the anal route, respectively; 27 patients from both).  The main outcome measures were depth and time of insertion, diagnostic and therapeutic yields, as well as complication rates.  Mean time of insertion was 70 +/- 30 mins and 90 +/- 35 mins from the oral and the anal route, respectively.  Length of insertion was 254 +/- 174 cm beyond the pylorus, 180 +/- 150 cm beyond the ileo-cecal valve, whereas the entire small bowel was completely explored in 10 patients.  Double balloon enteroscopy was diagnostic in 80 % of the patients: in 29/33 of patients with GI bleeding, in 1/5 patients with iron deficiency anemia and positive fecal occult blood testing, in 3/5 patients with chronic diarrhea, in 2/3 patients with abdominal pain, in 2/3 patients with GI cancer (follow-up), in all patients with suspected or refractory celiac disease, and in 2/3 patients with Crohn's disease.  Treatment was performed in 41.9 % of patients (22 polyps and 29 angioectesias).  No complications occurred.  The authors concluded that DBE is a safe and feasible diagnostic and therapeutic tool for suspected or documented small bowel diseases.  They claimed that at present, the best candidates for the procedure appear to be those with OGIB.

Matsumoto et al (2005a) compared the value of CE and DBE in the diagnosis of small intestinal pathology.  A total of 13 patients with OGIB and 9 patients with known GI polyposis were examined using antegrade or retrograde DBE, and the most distal or proximal site in the explored small intestine was marked by submucosal injection of sterilized ink.  Patients were then evaluated by CE.  Video images obtained by CE were reviewed by an observer who was blinded to DBE findings.  Double balloon enteroscopy identified positive findings in 54.5 % (12/22) patients.  Capsule endoscopy identified positive findings in the area explored by DBE in 36.4 % (8/22) patients, and in the unexplored area in  50.0 % (11/22) patients.  The overall diagnostic yield in the area explored by DBE did not differ between the two procedures.  The enteroscopic findings in the area explored by DBE were concordant in 12/13 patients with OGIB.  In patients with polyposis, the diagnoses were discordant in 3 patients, in whom CE failed to detect any polyp.  In 2/3 polyposis patients with concordant positive findings, DBE detected a larger number of polyps than CE did.  The authors concluded that DBE appears to be superior to CE in the diagnosis of small intestinal polyps, whereas the value for diagnosing OGIB is similar in the two procedures.  Furthermore, Matsumoto et al (2005b) stated that DBE is superior to push enteroscopy in exploration of the small intestine and in diagnostic yield for small intestinal pathology.

Nakamura et al (2006) evaluated the clinical effects of CE and DBE to consider their roles as well as the indications for the procedures in patients with suspected small bowel bleeding.  A total of 32 patients with OGIB were enrolled in the study; and 28 were examined with both methods.  Bleeding sources were categorized as A1 lesions (immediate hemostatic procedures required) or A2 lesions (close observation required).  Capsule endoscopy and DBE were evaluated with regard to whether or not they were capable of accessing the entire small bowel and provided a diagnosis, and the access and diagnostic rates were calculated.  On CE, 13 patients were diagnosed with A1 lesions and 6 with A2 lesions; on DBE, 11 had A1 lesions and 1 had an A2 lesion.  The access rate for the entire small intestine on CE was 90.6 % (29/32), significantly higher than with DBE at 62.5 % (10/16; p < 0.05).  The diagnostic rate on CE was 59.4 % (19/32), higher than with DBE at 42.9 % (12/28; p = 0.30), but not significantly different.  Among patients with A1 lesions who were diagnosed by means of DBE, histological diagnoses were obtained in 6/11, and 3 patients were treated.  The authors concluded that in many suspected small bowel bleeding cases, CE should be selected for the initial diagnosis and DBE for treatment or histopathological diagnosis after detection of the bleeding site on CE.

In a prospective study, Hadithi and colleagues (2006) compared the diagnostic detection rate of small bowel lesions using wireless video capsle endoscopy (VCE) with that using DBE in patients with OGIB.  Tolerance, adverse events, endoscopic interventions, and prognosis were used as secondary outcomes.  A total of 35 consecutive patients with OGIB were assessed (13 females and 22 males; mean age of 63.2 years; range of 19 to 86 years).  Small bowel abnormalities were detected using VCE in 80 % (28/35) patients with OGIB, compared with 60 % (21/35) patients using DBE (p = 0.01).  Both examinations were well-tolerated, but VCE was more acceptable to patients.  No major complication occurred after either examination.  Biopsies (n = 27), APC (n = 19), tattoo injection (n = 8), and polypectomy (n = 2) were feasible with DBE when indicated in 77 % (27/35) patients.  During a follow-up period of 5 months (range of 2 to 12 months), 74 % (26/35) patients remained clinically stable and did not require blood transfusions after DBE.  Eighteen (51 %) of those who remained clinically stable had received APC therapy.  The authors concluded that high detection rates of the causes of OGIB are feasible with VCE and DBE.  They noted that although the detection rate of VCE was superior, the findings of this study indicated that the procedures are complementary; and that an initial diagnostic imaging employing VCE might be followed by therapeutic and interventional DBE.

Monkemuller and associates (2006) examined the diagnostic yield of DBE, measured the frequency of management changes based on the results, and assessed the clinical outcome for patients undergoing the procedure.  Subjects included patients undergoing DBE using a Fujinon enteroscope (length 200 cm, diameter 8 mm) during a 11-month period.  All patients had previously undergone esophago-gastro-duodenoscopy and colonoscopy.  They underwent small bowel cleansing on the day before the procedure using a standard colon lavage solution.  A total of 70 DBE procedures were performed in 53 patients (19 women; 34 men, mean age of 60 years, range of 24 to 80 years) by the oral route in 46 cases and the anal route in 24 cases.  The indications for the examination were GI bleeding (n = 29), suspected Crohn's disease (n = 6), abdominal pain (n = 4), polyp removal or evaluation in polyposis syndromes (n = 6), chronic diarrhea (n = 4), and surveillance or tumor search (n = 4).  The mean duration of the procedure was 72 mins (range of 25 mins to 3 hrs).  The mean radiation exposure was 441 dGy/cm (range of 70 to 1462 dGy/cm), and the mean depth of small bowel insertion was 150 cm (range of 1 to 470 cm).  It was possible to evaluate the entire small bowel in 4 patients (8 %).  A new diagnosis was obtained in 26/53 patients (49 %).  The findings in the 70 procedures were angiodysplasia (n = 13), ulcerations or erosions (n = 5), jejunitis or ileitis (n = 5), tumors (n = 5), stenosis (n = 4), polyps (n = 5), Crohn's disease (n = 4), lymphangiectasias (n = 4), and normal (n = 17).  Double balloon enteroscopy resulted in a therapeutic intervention (endoscopic, medical or surgical, excluding blood transfusions) in 57 % (30/53) of the patients.  The only complication (1.4 %) observed was a single case of intra-procedural post-polypectomy bleeding, which resolved with injection of epinephrine.  The authors concluded that in almost 2/3 of the patients examined, DBE was clinically useful for obtaining a new diagnosis and starting new treatments, changing existing treatments, carrying out surgical intervention, or providing therapeutic endoscopy.  They stated that DBE is a useful and safe method of obtaining tissue for diagnosis, providing hemostasis, and carrying out polypectomy.

May et al (2007) stated that DBE is a new endoscopic tool that allows both diagnostic work-up as well as therapeutic interventions of small bowel diseases.  However, for a variety of reasons, endoscopic therapy appears to be more difficult to carry out deep in the small bowel than in the upper or lower GI tract.  These researchers evaluated the acute technical success and complication rates of DBE.  A total of 353 patients (152 women, 201 men; mean age of 60.3 +/- 17.1 years) with suspected or known small bowel disease underwent 635 consecutive DBE procedures.  The majority of the patients were suffering from mid-GI bleeding (n = 210, 60 %).  The overall diagnostic yield was 75 % (265/353) for relevant lesions in the small bowel.  The overall therapeutic yield was 67 % (236/353).  Endoscopic therapy was performed in 59 % of these patients (139/236).  All therapeutic interventions were performed in an inpatient manner.  The majority of the procedures were carried out with the patients under conscious sedation (n = 130, 73 %); sedation with propofol was administered in 37 (20.8 %) and with a combination of propofol and meperidine in 11 (6.2 %) investigations.  A total of 178 therapeutic procedures was carried out.  A median of 270 cm of the small bowel was visualized using the oral route and a median of 150 cm using the anal route.  The investigation time averaged 78 +/- 30 minutes.  The endoscopic treatments included APC (n = 102 treatment sessions), injection therapy (n = 2), a combination of APC and injection (n = 6), polypectomies (n = 46), dilation therapy (n = 18), and foreign-body extraction (n = 3).  In 6/178 cases (3.4 %), polypectomy (n = 2), dilation (n = 3), and implantation of a self-expanding metal stent (n = 1) could not be performed successfully for technical or anatomical reasons.  Severe treatment-related complications occurred in 6/178 therapeutic procedures (3.4 %) and 4/139 patients (2.9 %), consisting of bleeding (n = 2) and perforation (n = 3) during and after polypectomy of large polyps (greater than 3 cm in size), as well as one case of segmental enteritis after APC.  The authors concluded that endoscopic therapeutic interventions can be performed safely even in the more difficult conditions of the small bowel in the majority of patients.  Furthermore, polypectomy of large polyps appears to be the procedure associated with the highest risk.

Cazzato et al (2007) prospectively evaluated the diagnostic and therapeutic impact of DBE in patients with suspected or documented small bowel disease (n = 100).  Starting insertion route (anal or oral) of DBE was chosen according to the estimated location of the suspected lesions based on the clinical presentation and on the findings, when available, of previous endoscopic or radiological investigations.  Major indications for the procedures were acute recurrent or chronic mid-GI bleeding (n = 71), suspected GI tumors (n = 10), suspected Crohn's disease (n = 6), chronic abdominal pain and/or chronic diarrhea (n = 8), refractory celiac disease (n = 5).  A total of 118 DBE procedures were performed.  Oral and anal route DBE were performed in 54 and 28 patients, respectively, while 18 patients underwent a combination of both approaches.  The overall diagnostic yield of DBE was 69 %.  Most common pathological findings included angiodysplasias (n = 39), ulcerations and erosions of various etiologies (n = 21), tumors (n = 7) and ileal stenosis in patients with suspected Crohn's disease (n = 2).  In the 65 % of the patients examined, DBE findings influenced the subsequent clinical management (endoscopic, medical or surgical treatment).  No major adverse events related to the procedure occurred.  The authors concluded that DBE is a useful, safe and well-tolerated new method with a high diagnostic and therapeutic impact for the management of suspected or documented small bowel diseases.

Kita et al (2007) performed 419 enteroscopic examinations in 250 patients using the Fujinon DBE system.  Total enteroscopy was successfully achieved by the combination of both oral and anal approaches in 55 out of 71 cases in whom total enteroscopy was intended.  Of 250 patients, ulcerative and/or erosive lesions were found in 49 cases and tumors/polyps were found in 49 cases.  These investigators also found 26 cases of vascular lesion, including angiodysplasia.  Endoscopic treatments, including hemostasis using either clipping devices or electro-coagulation, polypectomy, endoscopic mucosal resection, balloon dilation, and stent placement was successfully carried out.  They concluded that DBE is an useful technique for the diagnosis as well as treatment of small intestinal disorders.

While Gurudu and Leighton (2006) stated that the ultimate role of DBE in the diagnosis and management of OGIB remains to be explored, Gerson (2005), in an editorial, stated that based on preliminary data in patients with OGIB, the diagnostic yield from DBE appears to surpass other imaging modalities while also allowing the opportunity for therapeutic intervention.  Moreover, Martins and Wassef (2006) noted that a number of prospective studies have reported that CE is the most sensitive imaging modality for identifying lesions in the small bowel and that DBE is the least invasive modality available for the management of these lesions.  Also, May and Ell (2006) noted that the diagnostic yield of DBE is high, at about 75 %, as is the therapeutic yield; and the key indication of DBE is mid-GI bleeding.  Concha et al (2007) stated that DBE may be the method of choice when therapeutic objectives are considered after wireless CE or whenever wireless CE is contra-indicated in patients with OGIB.

Additionally, an assessment by the Australian Medical Services Advisory Committee (MSAC, 2006) reached the following conclusions about DBE: "Double Balloon Enteroscopy (DBE) is a safe, minimally invasive technique for examining endoscopically the whole of the small intestine, allowing biopsy and certain therapeutic procedures at the same time.  The most appropriate comparator is intraoperative enteroscopy.  While there is no direct comparative data, it is likely to be safer to perform than the alternative, intraoperative enteroscopy.  DBE is effective in allowing enteroscopic assessment and some treatment of the entire small intestine.  Although more costly to Medicare than intraoperative enteroscopy, DBE is potentially cost saving for the entire health funding system.  MSAC recommends public funding for DBE for the diagnosis and treatment of patients with obscure gastrointestinal bleeding".

In a meta-analysis, Pasha and colleagues (2008) compared the diagnostic yield of CE with DBE in small bowel (SB) disease.  Data on diagnostic yield of CE and DBE were extracted, pooled, and analyzed.  The weighted incremental yield (IY(W)) (yield of CE–yield of DBE) of CE over DBE and 95 % confidence intervals (CIs) for pooled data were calculated using a fixed-effect model (FEM) for analyses without, and a random-effect model (REM) for analyses with, significant heterogeneity.  Eleven studies compared CE and DBE; the pooled overall yield for CE and DBE was 60 % (n = 397) and 57 % (n = 360), respectively (IY(W), 3 %; 95 % CI: -4 % to 10 %; p = 0.42; FEM).  Ten studies reported vascular findings; the pooled yield for CE and DBE was 24 % (n = 371) and 24 % (n = 364), respectively (IY(W), 0 %; 95 % CI: -5 % to 6 %; p = 0.88; REM).  Nine studies reported inflammatory findings; the pooled yield for CE and DBE was 18 % (n = 343) and 16 % (n = 336), respectively (IY(W), 0 %; 95 % CI: -5 % to 6 %; p = 0.89; FEM).  Nine studies reported polyps/tumors; the pooled yield for CE and DBE was 11 % (n = 343) and 11 % (n = 336), respectively (IY(W), -1 %; 95 % CI: -5 % to 4 %; p = 0.76; FEM).  The authors concluded that CE and DBE have comparable diagnostic yield in SB disease, including OGIB.  Capsule endoscopy should be the initial diagnostic test because of its non-invasive quality, tolerance, ability to view the entire SB, and for determining the initial route of DBE.  Because of its therapeutic capabilities, DBE may be indicated in patients with a positive finding on CE requiring a biopsy or therapeutic intervention, if suspicion for a SB lesion is high despite a negative CE, and in patients with active bleeding.

In a multi-center prospective study, Marmo et al (2009) evaluated diagnostic agreement between CE and DBE in patients with OGIB, and secondarily the diagnostic gain of DBE when CE detected only blood or clots in the small-bowel lumen.  A total of 193 patients (119 men, mean age of 61.6 +/- 16.2 years) first underwent CE and then DBE.  The most frequent positive findings at CE were vascular lesions (74 patients, 38.3 %), blood or clot in the lumen (34, 17.6 %), and tumor mass (20, 10.4 %).  The most frequent findings at DBE were vascular lesions (72 patients, 37.3 %), neoplasia (30, 15.5 %) and ulcers/inflammatory lesions (12, 6.2 %).  Overall, kappa coefficient was 0.46 (95 % CI: 0.38 to 0.54), with maximum concordance for vascular (0.72 [95 % CI: 0.59 to 0.84]) and inflammatory (0.78 [0.58 to 0.99]) lesions and minimum for polyps (0.46 [0.16 to 0.80]).  Blood in the lumen was the only positive finding at CE in 34 cases; of these, 12 had negative DBE findings whereas 10 had vascular lesions, 6 neoplasia, 1 ulcer, and 5 diverticula.  The authors concluded that CE and DBE have good agreement for vascular and inflammatory lesions but not for polyps or neoplasia.  Double balloon enteroscopy provides valuable adjunctive information, particularly in patients with neoplasia or polyp at CE; and DBE clarified the origin of bleeding in two-thirds of patients with CE showing only blood in the lumen.

In a review on the diagnosis and management of GI tract diseases, Akahoshi and colleagues (2006) stated that DBE is a feasible technique that allows adequate small and large bowel examination.

In a pilot study, Gay and Delvaux (2007) examined the use of DBE after failed conventional colonoscopy.  A total of 29 patients (5 men, 24 women; mean age of 54 years) in whom conventional colonoscopy had failed were included in this study.  Both the failed colonoscopy and the double-balloon colonoscopy procedures were performed under general anesthesia.  A prototype instrument (working length 152 cm, diameter 9.4 mm) designed to incorporate the principles of DBE was used.  The completeness of colonoscopy was assessed according to conventional criteria by the achievement of a stable position in the cecum.  The indicatons for the procedure, the time to reach the cecum, the need for fluoroscopic control, and adverse events were recorded.  The previous colonoscopy failed due adhesions (n = 16), or to long or fixed loops (n = 13).  Complete colonoscopy using the balloon method was achieved in 28/29 patients, taking an average time of 18 +/- 14 mins; a long sigmoid loop limited the examination to the left flexure in 1 patient.  Balloon colonoscopy using double-balloon methodology was used in 24 patients and the instrument was used without an overtube (i.e., using a single-balloon technique) in 5 patients.  Fluoroscopy was used in 16 patients to monitor endoscope progression.  No complications were reported.  The authors concluded that double-balloon colonoscopy enables full colonic examination in almost all patients with a previous incomplete colonoscopy.  The overtube should be used in most cases.  The use of fluoroscopic assessment of scope progression could be reduced further with increasing experience.

In a retrospective chart review, Pasha et al (2007) evaluated the completion rate of DBE for colon evaluation (ie, double-balloon colonoscopy) and therapeutic interventions after a prior incomplete colonoscopy by conventional colonoscope.  A total of 16 patients (11 women and 5 men; mean age of 69 years) had retrograde DBE between April 20, 2005 and February 8, 2006, after a prior incomplete colonoscopy.  Main outcome measures were completion rate of double-balloon colonoscopy, therapeutic success of standard procedures, as well as post-procedure complications.  A completion rate of 88 % (14 patients) was achieved with no procedure-related complications.  Double-balloon colonoscopy was generally performed with the patient under conscious sedation in a mean (standard deviation) total procedure time (including therapeutics) of 50.6 mins (SD, 15.2 mins).  The authors concluded that double-balloon colonoscopy has a high rate of effectiveness for completion of colon evaluation in patients with incomplete conventional colonoscopy.  It allows diagnostic and therapeutic interventions and can be performed with the patient under conscious sedation within a reasonable time.

Moreels et al (2010) examined if the therapeutic Fujinon double-balloon endoscope EN-450T5/20 is a valuable tool to intubate the cecum and to carry out all conventional endoscopic procedures after incomplete conventional colonoscopy.  A total of 45 patients with prior incomplete conventional colonoscopy were prospectively enrolled.  All but 3 procedures were performed under conscious sedation with the patient in the left lateral decubitus position without fluoroscopic guidance.  The cecum was reached in 42 of 45 patients (93 %) and in 62 % additional therapeutic interventions were carried out.  Double-balloon colonoscopy required less conscious sedation compared to conventional colonoscopy.  No external abdominal compression nor fluoroscopic control was used.  The insertion depth of the double-balloon endoscope did not exceed the working length of a conventional colonoscope.  The authors concluded that findings of the present study showed that the concept of DBE is a valuable alternative to reach the cecum after prior incomplete conventional colonoscopy, especially due to redundant colon and colonic loop formation. The procedure requires less conscious sedation and no fluoroscopic control, but allows all conventional endoscopic interventions.

Yano and Yamamoto (2009) stated that DBE is useful for cases of difficult colonoscopy, providing success rates of total colonoscopy between 88 to 100 %.   Furthermore, the Netherlands Association of Comprehensive Cancer Centres' practice guideline on hereditary colorectal cancer (2009) stated that in the case of incomplete colonoscopy, the colon should be imaged using another method (e.g., DBE, CT colonography, a double contrast barium enema).

Teshima et al (2011) performed a new meta-analysis comparing CE and DBE focused specifically on OGIB.  A comprehensive literature search was performed of comparative studies using both CE and DBE in patients with OGIB.  Data were extracted and analyzed to determine the weighted pooled diagnostic yields of each method and the odds ratio for the successful localization of a bleeding source.  A total of 10 eligible studies were identified.  The pooled diagnostic yield for CE was 62 % (95 % CI: 47.3 to 76.1) and for DBE was 56 % (95 % CI: 48.9 to 62.1), with an odds ratio for CE compared with DBE of 1.39 (95 % CI: 0.88 to 2.20; p = 0.16).  Subgroup analysis demonstrated the yield for DBE performed after a previously positive CE was 75.0 % (95 % CI: 60.1 to 90.0), with the odds ratio for successful diagnosis with DBE after a positive CE compared with DBE in all patients of 1.79 (95 % CI: 1.09 to 2.96; p = 0.02).  In contrast, the yield for DBE after a previously negative CE was only 27.5 % (95 % CI: 16.7 to 37.8).  The authors concluded that CE and DBE provide similar diagnostic yields in patients with OGIB.  However, the diagnostic yield of DBE is significantly higher when performed in patients with a positive CE.

Meckel's diverticulum (MD) is one of the most common congenital GI malformations.  It is difficult to make a pre-operative diagnosis of MD.  To-date, few data are available describing the diagnosis of MD by DBE and CE.  He and colleagues (2013) evaluated the value of DBE in the diagnosis of MD and comparatively evaluated the diagnostic yield of DBE and CE for MD.  A single-center study was performed on patients with a confirmed diagnosis of MD by surgery and post-operative pathology between January 2003 and December 2011.  A total of 74 patients (60 males) with a mean age of 29.0 +/- 14.3 years were analyzed; 33 (55.0 %) were between 21 and 40 years of age.  Gastro-intestinal bleeding was the major finding in 86.5 % of the patients who were referred for DBE or CE examination.  The mean duration of symptoms was 32.3 +/- 48.7 months.  In the 74 patients, the diagnostic yield of DBE for MD before surgery was 86.5 % (64/74), and correct diagnoses were made in the majority of cases by retrograde DBE, with a few cases by antegrade DBE.  In the 26 patients undergoing CE before DBE, the overall diagnostic yield of DBE was 84.6 %, significantly greater than that of CE (7.7 %, p < 0.000, McNemar's χ(2) test).  Poor agreement was found between the 2 modalities (kappa = 0.03).  The authors concluded that for patients who are highly suspected of having MD, DBE provides a safe, effective, and reliable means of diagnosis before surgery.  Moreover, these investigators noted that "A negative Meckel’s scan does not exclude the presence of MD; furthermore, a negative CE procedure also does not exclude important small bowel pathology, and additional invasive balloon-assisted enteroscopy remains mandatory if small bowl pathology is suspected even after a negative CE.  Considering the relatively small sample size in this study, our findings still remain to be further confirmed".

Also, an UpToDate review on "Meckel’s diverticulum" (Javid and Pauli, 2013) states that "Adult and pediatric patients with gastrointestinal bleeding are initially evaluated using standard algorithms.  Patients who present with gastrointestinal bleeding may undergo routine upper or lower gastrointestinal endoscopy, neither of which can demonstrate a Meckel’s diverticulum.  However, Meckel’s diverticulum has been identified using advanced endoscopy techniques (double balloon enteroscopy, capsule endoscopy), but these studies are not routinely obtained".

The American College of Radiology’s Appropriateness Criteria on "Suspected small-bowel obstruction" (Small et al, 2010) did not mention the use of DBE.  Furthermore, an UpToDate reviews on "Intussusception in children" (Kitagawa and Miqdady, 2013) does not mention the use of DBE as a therapeutic option.

In a multi-center, retrospective cohort study, Zhang et al (2013) stated that little is known about the clinical impact of DBE in patients with Peutz-Jeghers syndrome (PJS). These investigators evaluated the safety and effectiveness of DBE in the management of small-bowel polyps in PJS patients. Consecutive patients diagnosed with PJS who underwent DBE for polypectomy between January 2006 and August 2012 were included in this study.  In all cases, previous video capsule enteroscopy had shown at least 1 polyp greater than or equal to 10 mm in size.  A total of 25 patients (13 men; median age of 36 years; 14 with prior laparotomy) underwent 46 DBE procedures (1 to 5 per patient, 44 via oral route).  Polypectomy was performed in 39/46 DBEs.  A total of 214 polyps were removed (median size of 30 mm), with a median number of polypectomies per procedure of 5.0 (range of 1 to 18).  The estimated maximum-sizes of resected polyps significantly decreased at each session: 30.0, 25.0, 20.0, 15.0, and 17.5 mm (p = 0.02).  In 7 DBEs no polypectomy was performed (4-only minor polyps detected; 3-endoscopic irresectability).  Complications occurred in 3/39 of therapeutic procedures (2-minor delayed bleeding; 1-mucosal tear), all of them were dealt with conservative or endoscopic therapy.  A total of 6 patients underwent elective surgery post DBE due to polyps not amenable for endoscopic resection.  There were no small-bowel polyp related complications during a median follow-up of 56.5 months.  The authors concluded that DBE showed to be a safe and effective technique in the management of small-bowel polyps in PJS patients, allowing a pre-symptomatic and non-surgical approach.  These preliminary findings need to be validated by well-designed studies.

Furthermore, UpToDate reviews on "Peutz-Jeghers syndrome: Epidemiology, clinical manifestations, and diagnosis" (Lembo, 2014) and "Peutz-Jeghers syndrome and juvenile polyposis: Screening and management of patients and families" (Bonis et al, 2014) do not mention the use of DBE as a management tool.

Endoscopic Retrograde Cholangio-Pancreatography (ERCP) in Patients with Surgically Altered Gastro-Intestinal Anatomy

Osoegawa and colleagues (2012) examined the clinical outcome of DBE-assisted endoscopic retrograde cholangio-pancreatography (DB-ERCP) in patients with altered GI anatomy. Between September 2006 and April 2011, a total of 47 procedures of DB-ERCP were performed in 28 patients with a Roux-en-Y total gastrectomy (n = 11), Billroth II gastrectomy (n = 15), or Roux-en-Y anastomosis with hepatico-jejunostomy (HJ; n = 2). DB-ERCP was performed using a short-type DBE combined with several technical innovations such as using an endoscope attachment, marking by submucosal tattooing, selectively applying contrast medium, and CO2 insufflations. The papilla of Vater or HJ site was reached in its entirety with a 96 % success rate (45/47 procedures). There were no significant differences in the success rate of reaching the blind end with a DBE among Roux-en-Y total gastrectomy (96 %), Billroth II reconstruction (94 %), or pancreatoduodenectomy (100 %), respectively (p = 0.91). The total successful rate of cannulation and contrast enhancement of the target bile duct in patients whom the blind end was reached with a DBE was 40/45 procedures (89 %). Again, there were no significant differences in the success rate of cannulation and contrast enhancement of the target bile duct with a DBE among Roux-en-Y total gastrectomy (88 %), Billroth II reconstruction (89 %), or pancreatoduodenectomy (100 %), respectively (p = 0.67). Treatment was achieved in all 40 procedures (100 %) in patients whom the contrast enhancement of the bile duct was successful. Common endoscopic treatments were endoscopic biliary drainage (24 procedures) and extraction of stones (14 procedures). Biliary drainage was done by placement of plastic stents. Stones extraction was done by lithotomy with the mechanical lithotripter followed by extraction with a basket or by the balloon pull-through method. Endoscopic sphincterotomy was performed in 14 procedures with a needle precutting knife using a guide-wire. The mean total duration of the procedure was 93.6 ± 6.8 mins and the mean time required to reach the papilla was 30.5 ± 3.7 mins. The mean time required to reach the papilla tended to be shorter in Billroth II reconstruction (20.9 ± 5.8 mins) than that in Roux-en-Y total gastrectomy (37.1 ± 4.9 mins), but there was no significant difference (p = 0.09). A major complication occurred in 1 patient (3.5 %); perforation of the long limb in a patient with Billroth II anastomosis. The authors concluded that short-type DBE combined with several technical innovations enabled them to perform ERCP in most patients with altered GI anatomy.

Shimatani and colleagues (2014) stated that endoscopic treatment for pancreatobiliary diseases is less invasive than surgery and percutaneous trans-hepatic biliary drainage is highly beneficial to patients. The endoscopic approach is indicated for an increasing number of patients, including those who have undergone previous GI surgery, although these patients face 2 major challenges. First, the endoscopic approach to the afferent loop, blind end, and the site of choledocho-jejunostomy is difficult with the use of a conventional endoscope because of the distance from the gastro-jejunal anastomosis site, unusual anatomical features of the intestine such as its winding shape, and post-operative adhesion. Second, it is difficult to reach Vater's papilla or the site of choledocho-jejunostomy and to cannulate selectively into the pancreatic and/or biliary duct. The balloon-assisted endoscope (BAE), a recently developed technology, can be useful for carrying out ERCP in patients with surgically altered anatomy. The authors concluded that ERCP using the BAE is highly safe and effective in patients with altered GI anatomy, especially in patients with Roux-en-Y reconstruction.

Itokawa et al (2014) noted that in patients with Roux-en-Y HJ (HJ with R-Y) and Whipple resection, ERCP can be challenging. These investigators reported their experience with ERCP using BAE (BAE-ERCP) in patients with HJ with R-Y, and Whipple resection. BAE-ERCP procedures were carried out in 62 patients (HJ with R-Y:Whipple resection = 34:28). Overall, the rates of reaching the anastomosis were 85.3 % (29/34) in HJ with R-Y and 96.4 % (27/28) in Whipple resection. In terms of HJ with R-Y, insertion success rate by standard SBE was 89.3 % (25/28). Insertion success rate by short BAE, including SBE and DBE, was 50 % (3/6). There was a statistically significant difference of insertion success rate between standard long BE and short BE (p = 0.021). However, in the Whipple patients, insertion success rate by standard and short SBE was 93.8 % (15/16) and 91.7 % (11/12), respectively. Initial insertion success rate by short BAE in Whipple patients was significantly higher than in HJ with R-Y (91.7 % versus 50 %, p = 0.045). Therapeutic interventions included dilation of anastomosis stricture, stone extraction, endoscopic mechanical lithotripsy, biliary stent placement, stent extraction, endoscopic nasobiliary drainage, direct cholangioscopy, and electrohydraulic lithotripsy. The HJ with R-Y series and Whipple series treatment success rate was 90 % (18/20) and 95.0 % (19/20), respectively. The authors concluded that BAE-ERCP enabled ERCP to be carried out in patients with HJ. It is considered safe and feasible.

Skinner et al (2014) stated that OAE techniques have increased the ability to perform ERCP in patients with altered upper GI anatomy, such as RYGB. These researchers compared the safety and effectiveness of OAE-ERCP in patients with different configurations of upper GI anatomy. They performed a systematic review following a literature search for papers published between 1966 and August 2013. The following databases were searched: MEDLINE (via PubMed), Embase, Cochrane library, and Scopus. The following end-points were analyzed: diagnostic and therapeutic success rates, cannulation success rate, ERCP success rate, type of enteroscopy, types of intervention, complications. A total of 23 relevant reports on OAE procedures, including SBE, DBE, and spiral enteroscopy, were analyzed. Studies included a total of 945 procedures in 679 patients (age of 2 to 91 years) who had a variety of post-surgical upper GI anatomical configurations. Among patients who underwent RYGB, endoscopic success was 80 % and ERCP success was 70 %. In patients who had undergone a Roux-en-Y with either a pancreaticoduodenectomy, pylorus-preserving pancreaticoduodenectomy, or HJ, endoscopic success was 85 % and ERCP success was 76 %. In patients who had undergone a Billroth II procedure, endoscopic success was 96 % and ERCP success was 90 %. In patients with native papilla who underwent successful endoscopy, cannulation was successful in 90 % of patients compared with 92 % in patients with an anastomosis. Overall, ERCP success for all attempts was approximately 74 %. Interventions included sphincterotomy, pre-cut papillotomy, anastomotic stricturoplasty, stone removal, stent insertion, stent replacement, and balloon dilation of stenotic anastomosis. There were 32 major complications among the 945 procedures (3.4 %). The authors concluded that both endoscopic and ERCP success rates were highest in patients with Billroth II anatomy, followed by those with pancreaticoduodenectomy and HJ with R-Y; the lowest success rates were in patients with RYGB. Cannulation rates appeared to be equivalent in patients with both native papilla and biliary-enteric or pancreaticoenteric anastomoses. The diagnostic and therapeutic potential of balloon-assisted ERCP were high and the adverse event rate was low.

Furthermore, and UpToDate review on "Overview of deep small bowel enteroscopy" (Kita, 2015) lists "Diagnostic endoscopic retrograde cholangiopancreatography (ERCP) in patients with Roux-en-Y anatomy" as one of the diagnostic indications of deep small bowel enteroscopy.

Anvari and colleagues (2021) noted that performing ERCP in patients with surgically altered GI anatomy is challenging.  In a systematic review and meta-analysis, these researchers examined the safety and efficacy of DBE-ERCP in surgically altered anatomy.  They searched Medline, Embase, and CENTRAL databases through March 2020 for studies that conducted DBE-ERCP in patients with surgically altered GI anatomy.  Primary outcomes were enteroscopic, diagnostic, and procedural success rates of DBE-ERCP.  Secondary outcomes were adverse events (AEs) following DBE-ERCP.  Random effects meta-analysis of proportions was carried out when appropriate.  The Newcastle-Ottawa scale was used to examine risk of bias; heterogeneity was assessed using the inconsistency (I2) statistic.  A total of 24 studies involving 1,523 patients were included.  The pooled enteroscopic, diagnostic, and procedural success rates of DBE-ERCP were 90 % (95 % CI: 84 % to 94 %), 94 % (95 % CI: 88 % to 98 %), and 93 % (95 % CI: 88 % to 97 %); AEs were reported in 4 % (95 % CI: 3 % to 6 %) of cases.  Subgroup analysis of short-scope DBE-ERCP (less than 200 cm) and long-scope DBE-ERCP (200 cm) did not show substantial difference in outcomes.  The authors concluded that DBE is safe and effective for facilitating ERCP in patients with surgically altered GI anatomy; however, RCTs or comparative studies are needed to clarify its role compared to other modalities in surgically altered GI anatomy.

Detection of Small-Bowel Neuroendocrine Neoplasms

Bellutti et al (2009) evaluated the use of DBE for the detection of the primary tumor in patients with neuroendocrine tumors (NETs).  A total of 12 consecutive patients (4 men and 8 women) with suspected carcinoid syndrome, either metastatic to the liver (n = 5), symptoms of a neuroendocrine tumor with elevated tumor markers (n = 5), or OGIB (n = 2) underwent DBE for the search of the primary tumor or the source of bleeding.  All patients underwent abdominal sonography and a computed tomography (CT) scan, EGD, ileocolonoscopy, and octreotide scintigraphy prior to DBE.  Capsule endoscopy was performed in 4 patients.  A total of 17 DBE were performed in the 12 patients.  The CT scan and sonography of the abdomen as well as EGD and ileocolonoscopy were unable to detect the primary tumor in any patient.  A submucosal tumor of the ileum or the jejunum could be detected by DBE was detected in 7 patients (58 %) (anal route, n = 4; oral route, n = 3).  In 4 of these patients (33 %), this finding could be confirmed by the surgical resection of a NET.  In 2 patients (17 %) with a submucosal ileum protrusion suspicious for NET, laparotomy and intra-operative endoscopy did not confirm the tumor.  The authors concluded that the diagnostic yield of DBE for primary tumor search in patients with metastatic or suspected NET was 33 %.  They stated that although endoscopic small bowel investigation by DBE appears to enrich the diagnostic possibilities for the diagnosis of small bowel-NET, at the present time DBE should only be performed in selected cases, possibly based on a positive previous work-up.

Rossi and colleagues (2021) noted that the efficacy of DBE in the detection of small-bowel neuroendocrine neoplasm (sbNEN)is unknown.  In a prospective, single-center study, these investigators reported their experience for NENs.  All consecutive patients with a suspected sbNEN selected for diagnostic DBE were enrolled.  Between 2011 and 2016, a total of 25 patients were referred for a suspected sbNEN.  In 15/25 patients, a primary NEN was detected outside the small bowel; in 4, NEN was excluded.  After extensive work-up, 6 patients (4 males, median age of 50 years) underwent DBE (3 anterograde, 2 retrograde, and 1 both; median time of 60 mins; median insertion of 200 cm).  DBE was positive in 3 patients: 1 had an ileal 2-cm NEN G1, 1 had an ileal 1.3-cm NEN G1, and 1 had an ileal 1-cm NEN G2, all surgically removed.  Of the 3 other patients, 1 had a metastatic NEN of unknown primary, the other 2 had small intestinal NENs, both surgically removed (1.6-cm G1 and G2 NEN).  DBE showed a sensitivity of 60 % and, in absence of false-positive results, a specificity of 100 %; accuracy was 67 %.  No complications were observed.  The authors concluded that in line with data from the literature, the present series showed that DBE was a safe and effective procedure in the diagnosis of sbNENs.  Moreover, these researchers stated that further studies are needed to better clarify the diagnostic role of DBE in the neuroendocrine tumor setting and its relationship with other techniques.

Evaluation of Suspected Small Bowel Malignancies

In a retrospective, single-center study, Robles and colleagues (2015) evaluated the role of DBE in malignant small bowel tumors (MSBT). All consecutive patients who underwent a DBE with final diagnosis of a malignant neoplasm from 2004 to 2014 in the authors’ referral center were included. Patient demographic and clinical pathological characteristics were reviewed. Diagnosis of MSBT was achieved either by DBE directed biopsy with multiple tissue sampling, endoscopic findings or histological analysis of surgical specimen. These researchers analyzed the impact of DBE in outcome as well as clinical course of these patients. Of 627 patients, 28 (4.5 %) (mean age of 60 ± 17.3 years) underwent 30 procedures (25 anterograde, 5 retrograde) and were diagnosed of a malignant tumor. Patients presented with OGIB (n = 19, 67.9 %), occlusion syndrome (n = 7, 25 %) and diarrhea (n = 1, 3.6 %). They were diagnosed by DBE biopsy (n = 18, 64.3 %), histological analysis of surgical specimen (n = 7, 25 %) and unequivocal endoscopic findings (n = 2, 7.1 %). Gastro-intestinal stromal tumor (n = 8, 28.6 %), adenocarcinoma (n = 7, 25 %), lymphoma (n = 4, 14.3 %), neuroendocrine tumor (n = 4, 14.3 %), metastatic (n = 3, 10.7 %) and Kaposi sarcoma (n = 1, 3.6 %) were identified. Double balloon enteroscopy modified outcome in 7 cases (25 %), delaying or avoiding emergency surgery (n = 3), modifying surgery approach (n = 2) and indicating emergency SB partial resection instead of elective approach (n = 2). The authors concluded that DBE may be critical in the management of MSBT providing additional information that may be decisive in the clinical course of these patients.

Furthermore, and UpToDate review on "Overview of deep small bowel enteroscopy" (Kita, 2015) lists "Evaluation and tattooing of suspected small bowel malignancies (e.g., adenocarcinoma, lymphoma, GI stromal tumors, metastatic tumors)" as one of the diagnostic indications of deep small bowel enteroscopy.

Removal of Entrapped Foreign Body

May and colleagues (2005) described the technique of push-and-pull enteroscopy using DBE made it possible to remove swallowed foreign bodies causing intestinal obstruction deep in the small bowel without the need for surgical laparotomy. They reported 2 cases of enteroscopic removal of entrapped capsules. In 1 patient with acute recurrent intestinal bleeding and recurrent abdominal pain, Crohn's disease had been suspected on capsule endoscopy. The 2nd patient, with known Crohn's disease, was suffering from abdominal pain and underwent capsule endoscopy for investigation of the small bowel. Prior enterolysis had not revealed stenoses in either patient. An oral approach was chosen and the capsules were identified approximately 140 cm and 310 cm from the pylorus, respectively, in front of stenoses. The capsule endoscopes were removed successfully in both patients by means of push-and-pull enteroscopy using a new enteroscope device.

Van Weyenberg et al (2010) stated that capsule retention in the small bowel is a known complication of small-bowel video capsule endoscopy. Surgery is the most frequently used method of capsule retrieval. These investigators determined the incidence and causes of capsule retention and described the use of DBE as the primary technique used for capsule retrieval. A total of 904 patients who underwent small-bowel video capsule endoscopy were included in this a analysis. Main outcome measurements included the number of patients in whom capsule retention occurred and the number of patients in whom an entrapped capsule could be retrieved by using DBE. Capsule retention occurred in 8 patients (incidence 0.88 %; 95 % CI: 0.41 % to 1.80 %) and caused acute small-bowel obstruction in 6 patients. All retained capsules were successfully removed during DBE. Five patients underwent elective surgery to treat the underlying cause of capsule retention. One patient required emergency surgery because of multiple small-bowel perforations. The authors concluded that in their series, the incidence of capsule retention was low; and DBE is a reliable method for removing retained capsules and might prevent unnecessary surgery. If surgery is required, pre-operative capsule retrieval allows pre-operative diagnosis, adequate staging in case of malignancy, and optimal surgical planning.

In a retrospective case-series study, Makipour et al (2014) described an endoscopic method of retrieval retained video capsules using DBE. A total of 10 patients who underwent DBE for retrieval of a retained video capsule at 2 large tertiary referral academic centers from May 2007 to June 2013 were included in this study. Mean age of patients was 64.9 ± 18.1 years (4 females, 6 males). Five patients failed to pass the capsule as a result of an ileal or jejunal stricture (1 patient with ulcerative colitis; 4 patients with Crohn's disease); 2 patients had a small bowel stricture as a result of non-steroidal anti-inflammatory drug (NSAID) enteropathy; 1 patient had intermittent partial small bowel obstruction without evidence of a stricture; 1 patient had an obstructing malignant jejunal mass and 1 patient had a small bowel stricture as a result of radiation enteritis. Endoscopic removal via DBE was successful in 8 of 10 patients (80 %). The remaining 2 patients underwent surgical removal of the retained capsule. The 2 failed cases of capsule retrieval were both patients with suspected ileal disease. The authors concluded that the most common cause of capsule retention was underlying Crohn's disease; and DBE is an effective and minimally invasive method of capsule retrieval, including those patients with ileal disease, which has not been previously described. They stated that DBE can prevent unnecessary surgery while providing endoscopic therapy of inflammatory strictures by dilation.

Chen et al (2015) stated that recent case series have shown that enteroscopy is safe and effective to remove entrapped small bowel foreign bodies. However, the optimal timing for the foreign body retrieval in terms of duration of entrapment and when to consider surgical intervention are unknown. In this case-series study, these investigators reported that antegrade and retrograde enteroscopy can be used safely to retrieve foreign bodies entrapped in the small bowel for longer than 70 days. In total, 20 patients (mean age of 48 years; 11 females) with entrapped foreign bodies in the small intestine underwent antegrade, retrograde, or combined double balloon enteroscopy for retrieval of objects. Symptoms prompted removal of entrapped, non-sharp objects in all patients and included abdominal pain, nausea, and vomiting. The mean time of entrapment was 83 days (range of 4 to 272 days). There were 15 cases of retained video capsule endoscopy (VCE) with a mean entrapment time of 106 days (range of 7 to 272 days). Two VCEs could not be removed safely with enteroscopy. Other retained small bowel objects included in this study were nails and fish hooks. Their average entrapment time was 13 days (range of 4 to 43 days). Of the 30 enteroscopies, there was only 1 case (3 %) with a complication (perforation). The authors concluded that according to this case-series study, experienced endoscopists can safely and effectively retrieve foreign bodies in the small bowel, particularly VCE, that are retained for extended periods of time.

Furthermore, and UpToDate review on "Overview of deep small bowel enteroscopy" (Kita, 2015) lists "Foreign body retrieval (e.g., retained video capsule)" as one of the therapeutic indications of deep small bowel enteroscopy.

Peutz-Jeghers Syndrome

Goverde and colleagues (2017) noted that small-bowel surveillance with polypectomy of polyps greater than or equal to 15 mm prevents complications in patients with Peutz-Jeghers syndrome (PJS). These investigators compared magnetic resonance enteroclysis (MRE) and DBE for diagnostic yield of these polyps and for patient preference.  Patients prospectively underwent MRE followed by proximal DBE within 20 weeks.  Endoscopists were blinded to the MRE results.  These researchers compared number of polyps greater than or equal to 15 mm detected by MRE and DBE.  Patients' perceptions of both procedures were assessed using questionnaires.  A total of 15 PJS patients (67 % males, median age of 47 years) underwent both MRE and DBE.  Polyps greater than or equal to 15 mm were identified by MRE and/or DBE in 12/15 (80 %) patients.  There was no significant difference in the detection of polyps greater than or equal to 15 mm (38 by MRE versus 50 by DBE, p = 0.37).  Sensitivity for these polyps was 62 % (38/61) for MRE and 82 % (50/61) for DBE.  Patients' perceived shame and burden did not differ significantly between MRE and DBE.  Patients reported significantly more pain during preparation for MRE than for DBE (moderate versus no pain, p = 0.02), although perceived pain during the procedures was comparable (both mild, p = 0.89).  For future small-bowel surveillance 10/13 (77 %) patients preferred DBE over MRE (p = 0.09).  The authors concluded that these findings suggested that MRE and DBE have a comparable diagnostic yield of polyps greater than or equal to 15 mm.  However, DBE allowed for direct intervention and was preferred over MRE by most patients in this series.  They stated that larger cohorts of PJS patients are needed to fully evaluate the diagnostic yield of DBE compared with other modalities.

American College of Gastroenterology guidelines (Syngal et al, 2015) stated that the advent of DBE allows non-operative removal of polyps in many PJS cases. The European Society of Gastrointestinal Endoscopy (Pennazio et al, 2015) recommended device-assisted enteroscopy with timely polypectomy when large polyps (greater than 10  to 15  mm) are discovered by radiological examination or small-bowel capsule endoscopy in patients with PJS (strong recommendation, moderate quality evidence).  An UpToDate review on Peutz-Jeghers syndrome (Chung and Adar, 2016) stated that "[s]uccessful small bowel polypectomy using balloon-assisted enteroscopy has been described with both single and double balloon enteroscopies.  Endoscopists should be aware of possible challenges in performing double balloon enteroscopy in patients who have had previous abdominal surgery and may have peritoneal adhesions and altered anatomy.  Patients with PJS may also be at increased risk for perforation with polypectomy due to serosal invagination within the polyp stalk".

Wang and colleagues (2019) examined the role of DBE in treating intestinal polyps in patients with PJS.  All patients diagnosed with PJS who underwent a polypectomy under DBE from October 2006 to December 2018 were enrolled.  Their clinical records, including surgical history, the method of DBE insertion, the number of DBE procedures, and the maximum size and number of the resected polyps, were retrospectively reviewed.  A total of 97 patients were enrolled.  For both antegrade and retrograde DBE the maximum size of the resected polyps during the second hospitalization was significantly smaller than that during the 1st hospitalization (antegrade DBE: [2.13 ± 1.51] cm versus [3.63 ± 0.92] cm, p = 0.012; retrograde DBE: [1.20 ± 1.10] cm versus [2.95 ± 1.95] cm, p = 0.03), but was significantly larger than that during the 3rd hospitalization (antegrade DBE: [2.13 ± 1.51] cm versus [0.88 ± 0.70] cm, p = 0.012; retrograde DBE: [1.20 ± 1.10] cm versus [0.46 ± 0.40] cm, p = 0.048).  The interval between the 2nd and 3rd hospitalizations was significantly longer than that between the 1st and 2nd hospitalizations ([899.00 ± 382.12] days versus [537.27 ± 326.28] days, p = 0.027).  The success rate of total enteroscopy was 58.3 % (28/48), which was not affected by a history of laparotomy (61.5 % versus 52.4 %, p = 0.528).  The complication rate was 4.4 %.  The authors concluded that DBE was safe and effective for the diagnosis and treatment of intestinal polyps in patients with PJS.

Pyogenic Granuloma

Kikuchi and associates (2014) stated that a pyogenic granuloma (PG) is a capillary hemangioma that usually occurs on the skin or in the oral cavity; it is rarely observed in the GI tract. These investigators described a case of a 86-year old woman who presented with anemia.  Esophagogastroduodenoscopy and colonoscopy did not reveal any significant bleeding focus, but capsule endoscopy revealed a bleeding focus in the small intestine.  These researchers performed DBE and identified a 7-mm-diameter, reddish, sub-pedunculated, hemispheric polyp with a smooth surface in the small intestine, approximately 100 cm from the ileo-cecal valve.  The polyp was surgically removed, and the histological findings were consistent with a diagnosis of PG.

An UpToDate review on "Pyogenic granuloma (Lobular capillary hemangioma" (Lawley, 2016) does not mention DBE as a diagnostic tool.

Diagnosis of Suspected Meckel's Diverticulum

Hong and colleagues (2016) stated that various modalities have been used to diagnose Meckel's diverticulum (MD) in practice, but with their diagnostic accuracy deemed to be unsatisfactory for clinical practice.  Moreover, the usefulness of these modalities has not been evaluated for the diagnosis of bleeding MD in adults, due to the relative rarity of this condition.  In a multi-center study, these investigators determined the most accurate modality for the pre-operative diagnosis of bleeding MD in adults.  They conducted a retrospective analysis of the diagnostic accuracy for small bowel bleeding associated with MD of different modalities in patients greater than or equal to 18 years old who underwent assessment for MD, with confirmation at the time of explorative surgery.  Diagnostic accuracy of the different modalities was evaluated against the diagnosis obtained using technetium-99m pertechnetate scintigraphy (also known as Meckel's scan), considered to be the gold standard for the diagnosis of bleeding MD in pediatrics.  A total of 35 adults were identified with bleeding in MD over the study period, between 2005 and 2012.  Among these patients, only 24 (68.6 %) were diagnosed with MD pre-operatively.  The mean (95 % CI) diagnostic accuracy of selected modalities was as follows: Meckel’s scan, 21.4 % (5.7 % to 51.2%); CE, 35.7 % (14.0 % to 64.4 %); BAE, 85.0 % (61.1 % to 96.0 %); angiography, 0.0 % (0.0 % to 80.2 %); CT, 31.8 % (14.7 % to 54.9 %); and small-bowel follow-through, 62.5 % (25.9 % to 90.0 %).  The diagnostic accuracy was significantly higher for BAE than for Meckel’s scan (p = 0.001).  The authors concluded that among available diagnostic modalities, BAE provided the highest accuracy for the diagnosis of bleeding MD in adults and, therefore, should be considered as the preferred modality for pre-operative diagnosis.  Moreover, they stated that given the low diagnostic accuracy of Meckel’s scan within the adult population, BAE should be considered as a preferred pre-operative diagnostic modality in adult patients who have small-bowel bleeding and a suspected diagnosis of MD.  Thus, BAE might be effective in avoiding repeated diagnostic assessments, extensive exploration, or intra-operative enteroscopy in adult patients with suspected MD.

Gomes and co-workers (2016) stated that MD is estimated to affect 1 % to 2 % of the general population, and it represents a clinically silent finding of a congenital anomaly in up to 85 % of the cases.  In adults, MD may cause symptoms, such as overt occult lower GI bleeding.  The diagnostic imaging work-up includes CT scan, magnetic resonance imaging (MRI) enterography, technetium 99m scintigraphy (99mTc) using either labeled red blood cells or pertechnetate (known as the Meckel’s scan) and angiography.  The pre-operative detection rate of MD in adults is low, and many patients ultimately undergo exploratory laparoscopy.  More recently, however, endoscopic identification of MD has been possible with the use of BAE via direct luminal access, which also provides visualization of the diverticular ostium.  These investigators reviewed the diagnosis by DBE of 4 adults with symptomatic MD but who had negative diagnostic imaging work-ups.  The authors concluded that the findings of these cases indicated that BAE is a valuable diagnostic method and should be considered in adult patients who have suspected MD and indefinite findings on diagnostic imaging work-up, including negative Meckel’s scan.

Geng and associates (2017) noted that MD is the most common congenital anomaly of the GI tract.  These researchers evaluated the diagnostic value and safety of DBE for bleeding MD in children.  They included consecutive children who were highly suspected of MD between 2012 and 2013.  All patients underwent Meckel's scan; DBE was performed for patient with negative Meckel's scan.  An exploratory laparoscopy was performed in children with positive Meckel's scan or DBE.  A total of 42 patients met the inclusion criteria; 40 patients were confirmed to have MD by exploratory laparoscopy.  Meckel's scan was positive in 36 and negative in 6, with 34 as true-positives and 2 as false-positives; 6 patients with negative Meckel's scan were found to have MD by retrograde DBE and had immediate operation.  The distance from the diverticulum to the ileo-cecal valve was 40 to 60 cm.  Ectopic gastric mucosa was present in all 6 patients (100 %).  After operation, patients were followed in clinic for 20 to 42 months and no evidence of GI bleeding or recurrent anemia was observed.  The authors concluded that DBE can be a reliable diagnostic tool for bleeding Meckel's diverticulum in children with negative Meckel's scan.

Furthermore, an UpToDate review on "Meckel’s diverticulum" (Javid and Pauli, 2017) states that "Double-balloon enteroscopy (DBE) has also been reported in small case series in patients undergoing evaluation for gastrointestinal bleeding or abdominal pain.  Both prograde (per os) and retrograde (per rectum) DBE have been used to confirm the diagnosis of Meckel’s diverticulum based upon a suspicion from other imaging studies (e.g., CT, Meckel’s scan).  Endoscopy confirms the diagnosis by direct vision, but can also identify complications (mucosal ulceration, active bleeding), and in some cases, permits therapy".

Endoscopic Retrograde Cholangiopancreatography with Double Balloon Enteroscopy

In a meta-analysis, Shao and colleagues (2017) evaluated the safety and effectiveness of endoscopic retrograde cholangiopancreatography with DBE (DBE-ERCP) in patients with altered GI anatomy.  These investigators performed a comprehensive literature search on PubMed, Embase, and Cochrane library covering the period from January 2001 to December 2015.  Data were selected and abstracted from eligible studies and were pooled using a random-effects model; heterogeneity was assessed using the I2 test.  A total of 10 studies involving 301 patients were included in the analysis.  The pooled enteroscopy, diagnostic, and therapeutic success rates were 89.75 % [95 % CI: 79.65 to 94.30 %], 79.92 % (95 % CI: 68.06 to 89.59 %), and 63.55 % (95 % CI: 53.70 to 72.86 %), respectively; DBE-ERCP-related complications occurred in 18 patients including perforation (n = 5), pancreatitis (n = 3), cholangitis (n = 9), and bleeding (n = 1).  The incidence of DBE-ERCP-related complication was 6.27 % (95 % CI: 2.61 to 11.38 %).  The authors concluded that diagnostic and therapeutic DBE-ERCPs were feasible in patients with altered GI anatomy; and DBE-ERCP may be considered when pancreatico-biliary diseases occur in patients undergoing Roux-en-Y reconstruction or pancreatico-duodenectomy.

The authors noted that this meta-analysis had several limitations: Most studies included in this analysis had been performed in a diverse cohort of patients who have had different forms of surgery.  Thus, there was significant heterogeneity among studies in terms of procedural success rates.  Most of the included studies (9/10) were retrospective studies with innate bias.  Given the lack of long-term follow-up in some patients, the definitive effectiveness of therapeutic DBE-ERCP is unclear.  These researchers stated that studies with more patients and longer follow-up are needed to further verify the safety and effectiveness of DBE-ERCP in patients with altered gastrointestinal anatomy.

Dilation of Small Bowel Strictures in Crohn’s Disease

The American Society for Gastrointestinal Endoscopy (ASGE)’s guideline on "Enteroscopy" (Chauhan et al, 2015) stated that non-invasive imaging with CT and magnetic resonance enterography or direct visualization with wireless capsule endoscopy can provide valuable diagnostic information and direct therapy.  Enteroscopy technology and techniques have evolved significantly and allow diagnosis and therapy deep within the small bowel, previously attainable only with intra-operative enteroscopy.  Push enteroscopy, readily available in most endoscopy units, plays an important role in the evaluation and management of lesions located up to the proximal jejunum.  Currently available device-assisted enteroscopy systems, DBE, SBE, and spiral enteroscopy each have their technical nuances, clinical advantages, and limitations.  Moreover, the guideline mentioned enteral stricture dilation as an indication for enteroscopy generally.

Klag and co-workers (2017) stated that management of intestinal strictures associated with CD is clinically challenging despite advanced medical therapy directed toward mucosal healing to positively influence the natural course of CD-associated complications.  Although medical therapy is available for inflammatory strictures, therapy of fibro-stenotic strictures is the domain of surgery and endoscopy.  Endoscopic balloon dilation (EBD) has been recognized as a well-established 1st-line procedure in terms of safety and efficacy.  Although surgery is a valuable treatment modality for the management of CD-related strictures, EBD can help prevent multiple surgical interventions, which might in the long-term lead to a risk of short bowel syndrome.

Hirai (2017) noted that he therapeutic target in CD has been raised to the achievement of mucosal healing.  Although effective treatments that target cytokines and other molecules has been widely used for CD, intestinal strictures are still a major cause of surgery; EBD is known to be a safe and effective intervention for intestinal strictures in CD.  Since frequent intestinal resection often results in short bowel syndrome and can decrease the quality of life (QOL), EBD can help avoid surgery.  EBD with a conventional colonoscope for Crohn's strictures of the colon and ileo-colonic anastomosis has established safety and efficacy.  In addition, EBD using balloon-assisted enteroscopy has recently been applied for small bowel Crohn's strictures.  Although the evidence is not strong, EBD may become an alternative to surgery in small bowel strictures in CD.  The authors concluded that EBD and other new methods such as self-expanding stent implantation for Crohn's strictures may be useful and safe; however, it is important to address several issues regarding these interventions and to establish a protocol for combined therapies.

Lopes and associates (2017) evaluated the incidence of anastomotic strictures after intestinal resection in CD, demonstrate long-term safety and efficacy and safety of EBD in CD strictures and its impact on the diagnosis of subclinical post-operative endoscopic recurrence.  This was a retrospective single tertiary center study based on prospectively collected data between 2010 and 2015 including anastomotic and non-anastomotic strictures; 29 % of 162 CD patients included developed an anastomotic stricture; 43 patients with anastomotic strictures and 37 with non-anastomotic strictures underwent EBD; technical success was 97.7 % and 100 %, respectively, however, 63 % and 41 % needed repeat dilation during the 4.4-year follow-up.  Longer periods between surgery and index colonoscopy and higher lactoferrin levels were associated with the presence of stricture after surgery.  Calprotectin levels of greater than 83.35 μg/g and current or past history of smoking were associated with a shorter time until need for dilation (HR = 3.877, 95 % CI: 1.480 to 10.152 and HR = 3.041, 95 % CI: 1.213 to 7.627).  Anastomotic strictures had a greater need for repeat dilation (63 % versus 41 %, p = 0.047).  No differences were found between asymptomatic and symptomatic cohorts.  Disease recurrence diagnosis was only possible after EBD in 1/3 of patients.  The authors concluded that EBD is a safe and effective alternative to surgery, with a good short- and long-term outcome, postponing or even avoiding further surgery.  They stated that EBD may allow to diagnose disease recurrence in patients with no clinical signs/biomarkers of disease activity.

Baars and colleagues (2017) evaluated the therapeutic role of DBE in small bowel strictures and proposed a standard approach to small bowel strictures.  These investigators performed a systematic review of studies involving DBE in patients with small bowel strictures.  Only studies limited to small bowel strictures were included and those with ileo-colonic strictures were excluded.  A total 13 studies were included, in which 310 patients were dilated.  The average follow-up time was 31.8 months per patient.  The complication rate was 4.8 % per patient and 2.6 % per dilatation.  Surgery was avoided in 80 % of patients.  After the 1st dilatation, 46 % were treated with re-dilatation and only 17 % required surgery.  The authors concluded that DBE-assisted dilatation avoided surgery in 80 % of patients with small bowel strictures and was safe and effective.  They stated that DBE-assisted EBD should therefore be considered in all patients with small bowel strictures.

The Japanese Gastroenterological Endoscopy Society developed "Clinical Practice Guidelines for Enteroscopy in collaboration with the Japanese Society of Gastroenterology, the Japanese Gastroenterological Association, and the Japanese Association for Capsule Endoscopy (Yamamoto et al, 2017).  The guideline stated that balloon dilation for small bowel lesions of CD is indicated when the following conditions are all met:

• The patient presents with symptoms related to the stricture or the images show dilatation of the bowel proximal to the stricture
• The longitudinal length of the stricture is less than or equal to 5 cm
• The stricture is not associated with fistula, fissure, abscess, deep ulcer, or severe adhesion/flexure

Evidence level = I, Strength of recommendation = B

Bessissow and associates (2018) noted that symptomatic intestinal strictures develop in more than 1/3 of patients with CD within 10 years of disease onset.  Strictures can be inflammatory, fibrotic or mixed and result in a significant decline in QOL, frequently requiring surgery for palliation of symptoms.  Patients under the age of 40 with peri-anal disease are more likely to suffer from disabling ileo-colonic disease, thus may have a greater risk for fibro-stenotic strictures.  Therapeutic options for fibro-stenotic strictures are limited to endoscopic and surgical therapy; EBD appears to be a safe, less invasive and effective alternative modality to replace or defer surgery.  Serious complications are rare and occur in less than 3 % of procedures.  The authors stated that for non-complex strictures without adjacent fistulation or perforation that are less than 5 cm in length, EBD should be considered as 1st-line therapy.

Treatment of Post-Operative Bile Leakage in Persons Who had Undergone Hepatico-Jejunostomy

Matsumoto and colleagues (2018) stated that endoscopic treatment for post-operative bile is technically challenging in patients with altered GI anatomy.  In a case-series study, these researchers examined the effectiveness of using a short-type DBE to treat post-operative bile leakage following hepatico-jejunostomy (HJ).  These investigators noted that currently only a few case reports have described the treatment of post-operative bile leakage in patients with altered GI anatomy.  In this study, these investigators evaluated the effectiveness of DBE-endoscopic retrograde cholangiography (DBE-ERC) for the treatment of post-operative bile leakage in patients with altered GI anatomy by retrospectively evaluating their technical and clinical outcomes.  A total of 11 consecutive patients with HJ who underwent DBE-ERC for post-operative bile leakage at Okayama University Hospital between September 2010 and August 2016 were retrospectively analyzed.  Patients with a possible bile leak as determined by radiological studies and/or with increasing bilious output from a trans-abdominal drain placed during surgery were referred for DBE-ERC.  A bile leak was defined as leakage of contrast material from the biliary anastomosis or stump of the bile duct as indicated by fluoroscopy.  The authors stated that to their knowledge, this was the first case-series study of the endoscopic treatment of post-operative bile leakage using DBE.  They concluded that DBE-ERC was effective in patients experiencing bile leakage after HJ.  This procedure allowed more invasive percutaneous or surgical interventions to be avoided.  These preliminary findings need to be validated by well-designed studies.

Double-Balloon Enteroscopy for Diagnosis of Pelvic Mass Penetrating Intestine, Including Gossypiboma

Ishii and colleagues (2019) stated that gossypiboma is an iatrogenic granuloma caused by retained surgical gauze.  A 48-year old woman with a history of Cesarean section was incidentally found to have a pelvic mass on pre-operative CT examination for pectus excavatum.  Abdominal enhanced CT showed a 40-mm mass containing air in the pelvis.  The mass was suspected to be continuous with the ileum.  Trans-anal DBE showed a small fistula that was likely caused by penetration of the ileum dozens of centimeters from the ileocecal valve.  A yellow-brown, movable, and fibrous body was found in the fistula.  A part of the fibrous body was extracted with forceps.  Pathological examination revealed that it was gauze.  The authors concluded that this was the 1st reported case of an asymptomatic gossypiboma penetrating the ileum that was diagnosed with DBE.  The authors concluded that these findings suggested that DBE is useful for early diagnosis of pelvic mass penetrating intestine, including gossypiboma.  These preliminary findings need to be validated by further investigation.

Double-Balloon Enteroscopy-Facilitated Cyanoacrylate-Injection Endotherapy of Small-Bowel Varices

Despott and colleagues (2019) noted that small-bowel varices (SBVs) are an uncommon consequence of portal hypertension.  Radiologic intervention is usually considered for 1st-line management.  When radiologic intervention is not possible, management options become very limited.  In a retrospective review, these researchers examined the usefulness of DBE-facilitated cyanoacrylate-injection endotherapy of SBVs.  A total of 10 DBEs were performed in 6 patients (4 women; median age of 68.5 years).  No radiologic or surgical options were deemed feasible; 13 nests of SBVs were identified and injected with cyanoacrylate glue without hemorrhagic or embolic adverse events.  At the 30-day follow-up after therapy, only 1 patient had experienced a mild recurrence of mid-gut bleeding; this was managed conservatively; 1 patient presented with acute GI bleeding 7 months later, and a repeat DBE with cyanoacrylate-injection endotherapy was successfully performed; 1 patient succumbed to his underlying advanced cholangiocarcinoma after 2 months.  The remaining patients had a median follow-up of 12 months without any recurrent GI bleeding.  The authors concluded that DBE-facilitated cyanoacrylate-injection endotherapy of SBVs appeared to be a safe and effective option when other 1st-line options are not feasible.  These preliminary findings need to be validated by well-designed studies.

Differentiation of Isolated Small Bowel Crohn's Disease from Other Small Bowel Ulcerative Diseases

Niu et al (2022) stated that the diagnosis of isolated small bowel CD (ISBCD) has always been challenging.  In a retrospective, single-center study, these researchers compared the clinical features and DBE characteristics of ISBCD with those of other small bowel ulcerative diseases (OSBUD).  Patients with coexisting colonic and/or ileal valve lesions (n = 45) or whose final diagnosis was not determined (n = 29) were excluded.  A total of 139 patients with ISBCD and 62 patients with OSBUD found by DBE were analyzed.  The age of ISBCD onset was lower than that of OSBUD (odds ratio [OR] 0.957, 95 % CI: 0.938 to 0.977, p < 0.001).  Abdominal pain was more common in ISBCD (OR 4.986, 95 % CI: 2.539 to 9.792, p < 0.001).  Elevated fibrinogen levels (OR 1.431, 95 % CI: 1.022 to 2.003, p = 0.037) and lower levels of D-dimer (OR 0.999, 95 % CI: 0.999 to 1.000, p = 0.017) were also more supportive of the diagnosis of ISBCD.  NSAIDs used for more than 2 weeks decreased the probability of a diagnosis of ISBCD (OR 0.173, 95 % CI: 0.043-0.695, p = 0.013).  Abdominal CT revealed a higher proportion of skip lesions in ISBCD than in OSBUD (OR 9.728, 95 % CI: 3.676 to 25.742, p < 0.001).  The ulcers of ISBCD were more distributed in the ileum (111 (79.9 %) versus 29 (46.8 %), p < 0.001), and their main morphology differed in different intestinal segments.  Longitudinal ulcers (OR 14.293, 95 % CI: 4.920 to 41.518, p < 0.001) and large ulcer (OR 0.128, 95 % CI: 0.044 to 0.374, p < 0.001) contributed to the differentiation of ISBCD from OSBUD.  These investigators constructed a diagnostic model, ISBCD index (AUROC = 0.877, 95 % CI: 0.830 to 0.925), using multi-factorial binary logistic regression to help distinguish between these 2 groups of diseases.  The authors concluded that clinical features, laboratory tests, abdominal CT, DBE characteristics, and pathology aided in differentiating ISBCD from OSBUD.  Moreover, these researchers stated that the conclusions from this retrospective, single-center trial had several drawbacks and the possibility of bias; thus, a large, multi-center study on the ulcerative characteristics of ISBCD observed by DBE is needed.

Treatment of Jejunal Varix with High Transfusion Requirement

Jejunal varices are an uncommon manifestation of portal hypertension and are rarely symptomatic.  Acute bleeding has been reported in 5.5 % of patients with portal hypertension and small bowel varices.  Traditionally, jejunal variceal bleeding has been treated surgically.  In a single-case study, Martinez et al (2023) describe a patient with jejunal varix with high transfusion requirement.  The patient was treated by DBE with cyanoacrylate/ lipiodol with radiological control.  The subject had no GI hemorrhage or transfusion requirement at 8-month follow-up.  The clinical effectiveness of this new therapeutic possibility needs to be further investigated in well-designed studies.

An UpToDate review on “Approach to acute upper gastrointestinal bleeding in adults” (Saltzman, 2022) states that “For patients with active/brisk bleeding and hypovolemia, transfusion should be guided by hemodynamic parameters (e.g., pulse and blood pressure), the pace of the bleeding, estimated blood loss, and the ability to stop the bleeding, rather than by serial hemoglobin measurements.  If the initial hemoglobin level is low (< 7 g/dL) transfusions should be initiated.  In an acutely hemorrhaging patient, however, transfusion support should not be delayed while awaiting laboratory test results”.

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Glossary of Terms (remove section if not needed)

Table: Glossary of Terms

Term	Definition
First-degree blood relative	Parent, full-sibling, child

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Appendix (remove section if not needed)

Appendix content

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References