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How to increase adherence to antidepressants

 

Depression responds well to antidepressant therapy.1 Those who adhere to therapy early and continue to take medication as prescribed are more likely to recover from depression and avoid future relapse.2 The most recent HEDIS® (Healthcare Effectiveness Data and Information Set) data available show that 79.45% of Aetna® members comply with their antidepressant medication plan during the first 12 weeks of treatment and that 65.53% of members remain compliant 6 months or more.

 

You can help improve adherence

 

Using the Mayo Clinic depression medication decision choice aid can help you work with your patients to select the medication that’s right for them. Using the tool can improve the decision-making process and may lead to an increase in medication adherence and improve quality outcomes for your patients.3

 

Failure to adhere to medication can lead to high-risk outcomes, such as poor quality of life, comorbidity-related death and suicide attempts.4 This can affect patients who:

 

  • Don’t take their medicine during the first six weeks of therapy
  • Have chronic conditions such as chronic obstructive pulmonary disease, diabetes, heart disease or myocardial infarction

 

Questions?

 

To learn more, review the American Psychological Association clinical practice guidelines for the treatment of depression.

 

1Cipriani A, Furukawa T, Salanti G, et al. Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis. The Lancet. April 7, 2018; 91: 1357–1366. Accessed March 11, 2022.

 

2Rush AJ, Thase ME. Improving depression outcome by patient-centered medical management. Focus: The Journal of Lifelong Learning in Psychiatry. Spring 2020; 18(2): 244–254. Accessed March 11, 2022.

 

3LeBlanc A, Herrin J, Williams MD, et al. Shared decision making for antidepressants in primary care: a cluster randomized trial. JAMA Internal Medicine. 2015; 175(11): 1761–1770. Accessed March 11, 2022.

 

4Ho SW, Jacob SA, Tangiisuran B. Barriers and facilitators of adherence to antidepressants among outpatients with major depressive disorder: a qualitative study. PLoS One. June 14, 2017; 12(6): 1–14. Accessed March 11, 2022.

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